Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone

The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a...

Full description

Saved in:
Bibliographic Details
Published inPsychopharmacology Vol. 57; no. 1; p. 103
Main Authors Naik, S R, Naid, P R, Sheth, U K
Format Journal Article
LanguageEnglish
Published Germany 01.01.1978
Subjects
Aminobutyrates - physiology
Animals
Anticonvulsants
Brain Chemistry
Cerebellum - metabolism
Diazepam - pharmacology
gamma-Aminobutyric Acid - physiology
Hypnotics and Sedatives
Male
Methaqualone - pharmacology
Muscle Relaxation - drug effects
Phenobarbital - pharmacology
Rats
Seizures - chemically induced
Online AccessGet more information

Cover

More Information
Summary:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective inhibitor of strychnine convulsion. Methaqualone elicits muscle-relaxant, sedative, and anticonvulsant effects at different dose levels. At low, nonsedative doses the drug produces anticonvulsant effects, and at higher doses, muscle-relaxant and sedative effects. It appears that the mechanism(s) of action of methaqualone in on GABA deficiency or receptor blockade, rather than on glycine receptors.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00426965