Paracrine communication between malignant and non-malignant prostate epithelial cells in culture alters growth rate, matrix protease secretion and in vitro invasion

• Published in: Clinical & experimental metastasis Vol. 19; no. 8; pp. 727 - 733
• Main Authors: Greiff, Andrea H, Fischer, William M, Sehgal, Inder
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.2002
• Subjects: Cell Communication; Cell Division; Cell Transformation, Neoplastic; Coculture Techniques; Culture Media, Conditioned; Humans; Male; Matrix Metalloproteinases - metabolism; Neoplasm Invasiveness; Prostate - cytology; Prostate - pathology; Prostate - physiopathology; Prostatic Neoplasms - pathology; Prostatic Neoplasms - physiopathology; Tumor Cells, Cultured

Epithelial cancer cell invasion is facilitated by stromal cells, immune cells, endothelial cells and other epithelial cells. We have used two human papilloma immortalized prostate cell lines, CA-HPV-10 from a carcinoma and PZ-HPV-7 cells from normal prostatic epithelium to study cell-cell influences...