High-Throughput 96-Well Nanogroove-Enhanced Electrical Impedance Biosensor for Real-Time Label-Free Cancer Drug Screening

• Published in: Advanced healthcare materials Vol. 14; no. 22; p. e2402057
• Main Authors: Choi, Jong Seob, Park, Hye-Bin, Lee, Su Han, Kim, Byunggik, Lee, Jihoon, Sung, Sang-Keun, Su, Chia-Yi, Lee, JuKyung, Jang, Seongjun, Lee, Yongjin, Lee, Jung Hyun, Kim, Hyung Jin, Kim, Deok-Ho
• Format: Journal Article
• Language: English
• Published: Germany 18.06.2025
• Subjects: Antineoplastic Agents - pharmacology; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Drug Screening Assays, Antitumor - instrumentation; Drug Screening Assays, Antitumor - methods; Electric Impedance; High-Throughput Screening Assays - methods; Humans; MCF-7 Cells; high‐throughput drug screening; interdigitated electrode arrays; nanopatterned substrates; electrochemical sensors; real‐time impedance sensing

This study advances bioelectronic platforms and cellular behavior analysis by enhancing the precision and scalability of nanopatterned membranes integrated with electrode arrays for real-time, high-throughput monitoring. By employing self-assembled monolayers (SAMs) and optimizing imprinting paramet...