Does cellular elastic modulus change due to subculture and fixation: an atomic force microscopy study of nucleus pulposus cells in vitro

• Published in: European physical journal plus Vol. 138; no. 10; p. 960
• Main Authors: Xiao, Bowei, Zhou, Tianchi, Huang, Juying, Rong, Tianhua, Wu, Bingxuan, Liu, Baoge
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 29.10.2023; Springer Nature B.V
• Subjects: Apoptosis; Applied and Technical Physics; Atomic; Atomic force microscopy; Back surgery; Biomechanics; Cell culture; Complex Systems; Condensed Matter Physics; Degeneration; Fixation; Force; Intervertebral discs; Mathematical and Computational Physics; Mechanical properties; Microscopy; Modulus of elasticity; Molecular; Morphology; Necrosis; Nuclei (cytology); Optical and Plasma Physics; Pathogenesis; Physics; Physics and Astronomy; Regular Article; Software; Theoretical; Germany

Cervical spinal degenerative disease (CSDD) is the progressive deterioration of cervical intervertebral disk (IVD) and is strongly related to the degeneration, necrosis, and apoptosis of nucleus pulposus cells (NPCs). The cellular mechanics of cervical NPCs is essential for the biomechanics of degen...