Human TH2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1

• Published in: Journal of allergy and clinical immunology Vol. 129; no. 4; pp. 1136 - 1142
• Main Authors: Parmentier, Celine N., Fuerst, Elisabeth, McDonald, Joanne, Bowen, Holly, Lee, Tak H., Pease, James E., Woszczek, Grzegorz, Cousins, David J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2012; Elsevier; Elsevier Limited
• Subjects: Airway management; Animal models; Antagonists; Asthma; Biological and medical sciences; Bronchoconstriction; Calcium; Cell adhesion & migration; Chemotaxis; Cloning; Cyclic AMP; CYSLTR1; cysteinyl leukotriene receptor 1 protein; cysteinyl leukotrienes; Data processing; Differentiation; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Genomics; Helper cells; Human; Immunopathology; Inflammation; Leukotrienes; Lipids; LTD4; Lymphocytes; Lymphocytes T; Medical sciences; mRNA; Mucus; Pathogenesis; Polymerase chain reaction; Proteins; Respiratory tract; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Signal transduction; Software; Studies; TH1; TH2; United Kingdom > UK; Human; P2RY12; GPR17; P2Y12; LT; cAMP; CysLT; cysteinyl leukotriene receptor 1 protein; CYSLTR1; cysteinyl leukotrienes; LTD4; TH1; TH2; chemotaxis; CysLT1; Immunopathology; Leukotriene receptor; Arachidonic acid derivatives; Th1 lymphocyte; Helper cell; Chemotaxis; Protein; Leukotriene; 1; 2; Immunology; T; Eicosanoid; T-Lymphocyte; Th2 lymphocyte; LTD

Allergic asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness associated with TH2 cell–mediated inflammation. Cysteinyl leukotrienes (CysLTs) are potent lipid mediators involved in bronchoconstriction, mucus secretion, and cell trafficking in asthmatic patients....