In vivo Realization of Dual Photodynamic and Photothermal Therapy for Melanoma by Mitochondria Targeting Dinuclear Ruthenium Complexes under Civil Infrared Low‐power Laser

• Published in: Angewandte Chemie International Edition Vol. 61; no. 38; pp. e202208721 - n/a
• Main Authors: Wang, Meng‐Fan, Yang, Rong, Tang, Shi‐Jie, Deng, Yu‐Ang, Li, Guo‐Kui, Zhang, Dan, Chen, Daomei, Ren, Xiaoxia, Gao, Feng
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 19.09.2022
• Edition: International ed. in English
• Subjects: Antitumor; Biocompatibility; Cytotoxicity; Drug development; Infrared lasers; Irradiation; Melanoma; Mitochondria; Photodynamic; Photodynamic therapy; Photothermal; Photothermal conversion; Radiation dosage; Ruthenium; Ruthenium Complex; Ruthenium compounds; Singlet oxygen; Thrombolytic drugs; Toxicity; Tumors; Two-Photon

A series of dinuclear RuII complexes with extremely high TPA cross sections in the range of 800–900 nm have been designed. The amphiphilic complex Ru3 containing tert‐butyl groups has balanced performance in singlet oxygen generation and photothermal conversion and becomes the ideal drug candidate o...