Control of Hazardous Processes in Flow: Synthesis of 2-Nitroethanol

• Published in: Journal of flow chemistry Vol. 4; no. 1; pp. 26 - 34
• Main Authors: Roberge, Dominique M., Noti, Christian, Irle, Eberhard, Eyholzer, Markus, Rittiner, Bruno, Penn, Gerhard, Sedelmeier, Gottfried, Schenkel, Berthold
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2014
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Green Chemistry; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Nanochemistry; Organic Chemistry; continuous flow; hazardous chemistry; formaldehyde; energetic compound; 2-nitroethanol; paraformaldehyde; microreactor technology; nitromethane; Henry reaction

After a short section of safety aspects related to 2-nitroethanol, the paper describes a powerful methodology for developing flow processes based on a proof of concept (1), an optimization and modeling analysis (2), and a long run study in a mini-plant (3). The proof of concept is the initial stage...