A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF LEVOBUPIVACAINE WITH CLONIDINE AND LEVOBUPIVACAINE WITH DEXMEDETOMIDINE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK

• Published in: Journal of evolution of medical and dental sciences Vol. 5; no. 19; pp. 925 - 929
• Main Authors: Tandon, Neelima, Gupta, Manish, Agrawal, Jitendra, Mathur, Ashish, Gupta, Suman, Yadav, Satyendra, Goyal, Preeti, Choudhary, Bhanu
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 07.03.2016
• Subjects: Clonidine; Comparative analysis; Dexmedetomidine; Methods; Nerve block
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2016/215

OBJECTIVE The objective of this study is to compare clonidine and dexmedetomidine as an adjuvant to levobupivacaine in supraclavicular brachial plexus block with respect to onset, duration of sensory and motor block and duration of analgesia. MATERIALS AND METHODS A total of 90 ASA grade I and II patients of either sex, aged 18-60 yrs. scheduled for elective upper limb surgeries under supraclavicular brachial plexus block were divided into 3 equal groups in a randomized fashion. Group L (n=30) received 1 mL NS, group LC (=30) received 1 mL (150 g) clonidine and group LD (n=30) received 1 mL (100 g) dexmedetomidine added to 30 mL of 0.5% levobupivacaine. Onset and recovery time of sensory and motor block, duration of analgesia and quality of block were studied in all three groups. RESULTS Onset time of sensory and motor blockade was 12.43 [+ or -] 2.56 min and 17.96 [+ or -] 3.05 min respectively in group L, 9.03 [+ or -] 1.60 min and 15.00 [+ or -] 2.40 min respectively in group LC and 8.13 [+ or -] 2.51 min and 12.13 [+ or -] 2.89 min respectively in group LD. Duration of sensory and motor blockade was 660.16 [+ or -] 44.28 min and 535.33 [+ or -] 50.66 min respectively in group L, 880.16 [+ or -] 55.48 min and 771.83 [+ or -] 54.19 min respectively in group LC and 930.66 [+ or -] 48.02 min and 811.83 [+ or -] 52.08 min respectively in group LD. Time of rescue analgesia was 728.86 [+ or -] 45.12 min in group L, 1013.5 [+ or -] 59.01 min in group LC and 1159.8 [+ or -] 56.8 min in group LD (p<0.05). CONCLUSION Dexmedetomidine when added to LA in supraclavicular brachial plexus block prolongs the duration of sensory and motor blockade and also the time for rescue analgesia as compared to clonidine. Dexmedetomidine also enhances quality of block (LD>LC>C). KEYWORDS Supraclavicular Brachial Plexus Block, Levobupivacaine, Clonidine, Dexmedetomidine.