Characterization of human gliomas by a monoclonal antibody both on tissue culture and paraffin-embedded sections

A monoclonal antibody designated OITIC3-11 was produced against GFAP positive human glioblastoma multiforme tumour cells. The specificity of the monoclonal antibody was tested on different types of human brain tumours and on normal adult brain both on tissue cultures and paraffin-embedded sections....

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Bibliographic Details
Published inNeurological research (New York) Vol. 14; no. 3; p. 263
Main Authors Sipos, L, Wakabayashi, T, Szeifert, G T, Fazekas, I, Afra, D
Format Journal Article
LanguageEnglish
Published England 01.06.1992
Subjects
Animals
Antibodies, Monoclonal
Astrocytoma - pathology
Brain - pathology
Brain Neoplasms - classification
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Female
Ganglioneuroma - pathology
Glial Fibrillary Acidic Protein - analysis
Glioblastoma - pathology
Glioma - classification
Glioma - pathology
Glioma - surgery
Humans
Immunohistochemistry
Mice
Mice, Inbred BALB C - immunology
Tumor Cells, Cultured
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Summary:A monoclonal antibody designated OITIC3-11 was produced against GFAP positive human glioblastoma multiforme tumour cells. The specificity of the monoclonal antibody was tested on different types of human brain tumours and on normal adult brain both on tissue cultures and paraffin-embedded sections. The OITIC3-11 monoclonal antibody reacted with 16 of 18 malignant and 1 of 6 benign gliomas but did not react with meningioma, pituitary adenoma, metastatic brain tumours and normal adult brain tissue.
ISSN:0161-6412
DOI:10.1080/01616412.1992.11740067