Bioequivalence evaluation of 2 brands of cefuroxime axetil 250 mg tablets in healthy human volunteers

• Published in: International journal of clinical pharmacology and therapeutics Vol. 42; no. 7; p. 367
• Main Authors: Pistos, C, Michalea, S, Kalovidouris, M, Kontopoulos, G, Georgarakis, M
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2004
• Subjects: Administration, Oral; Adult; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Cefuroxime - analogs & derivatives; Cefuroxime - blood; Cefuroxime - pharmacokinetics; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Half-Life; Humans; Male; Tablets; Therapeutic Equivalency; Time Factors

To assess the bioequivalence of 2 oral cefuroxime axetil (250 mg) tablets formulation. The reference preparation was Zinadol/Glaxo Wellcome, England, while the test preparation was cefuroxime axetil/Pharmathen, Athens, Greece. The study was an open, randomized, 2-period, 2-sequence, 2-treatment cros...