Maternal obesity aggravates the abnormality of porcine placenta by increasing N6-methyladenosine

• Published in: International Journal of Obesity Vol. 42; no. 10; pp. 1812 - 1820
• Main Authors: Song, Tongxing, Lu, Jinxin, Deng, Zhao, Xu, Tao, Yang, Yue, Wei, Hongkui, Li, Shengqing, Jiang, Siwen, Peng, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Nature Publishing Group
• Subjects: 38; 38/1; 38/22; 38/77; 38/89; 45; 45/15; 45/91; 692/163/2743/2037; 692/163/2743/393; Angiogenesis; Birth weight; Blood vessels; Body weight; Epidemiology; Fetuses; Gene expression; Gene regulation; Genes; Health Promotion and Disease Prevention; Internal Medicine; Lipid metabolism; Lipids; Low birth weight; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Methyltransferase; mRNA; N6-methyladenosine; Obesity; Overweight; Placenta; Postpartum period; Pregnancy complications; Proteins; Public Health; Ribonucleic acid; RNA; RNA modification; Test procedures; Weaning
• ISSN: 0307-0565; 1476-5497; 1476-5497
• DOI: 10.1038/s41366-018-0113-2

Background The growing prevalence of overweight or obese pregnancies shows an increasing risk for aberrant fetal growth and postnatal complications. Maternal obesity is associated with low birth weight (LBW) of piglets. However, the development of LBW from maternal obesity is not well understood. Ob...