Anticancer Effects and Molecular Mechanisms of Gossypin on Phosphatidylinositol 3-Kinase/Protein Kinase B Inhibition in Human Nonsmall Cell Lung Cancer Cell Line, A549

• Published in: Natural product communications Vol. 18; no. 8
• Main Authors: Lee, Seong Uk, Kim, Yoon Hee
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2023
• Subjects: gossypin; phosphatidylinositol 3-kinase/protein kinase B signaling pathway; flavonoid; nonsmall cell lung cancer; anticancer effect

Nonsmall cell lung cancer (NSCLC) accounts for approximately 80%–85% of all lung cancer patients. Gossypin, a flavonoid contained in Hibiscus vitifolius, has been reported as a potential anticancer agent. However, the effect of gossypin on NSCLC has not been elucidated. Herein, we evaluated the anti...