Dopamine receptor density and white mater integrity: 18F-fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects

• Published in: Brain imaging and behavior Vol. 14; no. 3; pp. 736 - 752
• Main Authors: Mitelman, Serge A., Buchsbaum, Monte S., Christian, Bradley T., Merrill, Brian M., Buchsbaum, Bradley R., Mukherjee, Jogeshwar, Lehrer, Douglas S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2020; Springer Nature B.V
• Subjects: Animal models; Anisotropy; Attention deficit hyperactivity disorder; Binding; Biomedical and Life Sciences; Biomedicine; Brain; Corpus callosum; Correlation; Cortex; Density; Diagnostic systems; Dopamine; Dopamine D2 receptors; Dopamine D3 receptors; Emission analysis; Fluorine isotopes; Frontal lobe; Integrity; Magnetic resonance imaging; Mathematical analysis; Medical imaging; Mental disorders; Myelin; Myelination; Neuroimaging; Neurology; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Permutations; Positron emission; Positron emission tomography; Psychiatry; Receptor density; Schizophrenia; Substantia alba; Substantia grisea; Tensors; Thalamic nuclei; Thalamus; Tomography; Schizophrenia; Thalamus; Dopamine; Myelin; White matter; Hyperdopaminergia

Dopaminergic dysfunction and changes in white matter integrity are among the most replicated findings in schizophrenia. A modulating role of dopamine in myelin formation has been proposed in animal models and healthy human brain, but has not yet been systematically explored in schizophrenia. We used...