Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

• Published in: Blood Vol. 98; no. 9; pp. 2626 - 2632
• Main Authors: Wurbel, Marc-André, Malissen, Marie, Guy-Grand, Delphine, Meffre, Eric, Nussenzweig, Michel C., Richelme, Mireille, Carrier, Alice, Malissen, Bernard
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.11.2001; The Americain Society of Hematology
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Biological and medical sciences; Experimental and animal immunopathology. Animal models; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Immunobiology; Immunopathology; Lymphokines, interleukins ( function, expression); Medical sciences; Regulatory factors and their cellular receptors; Animal model; Lymphopoiesis; Thymus gland; CCR9 chemokine receptor; γ/δ T cell receptor; Thymocyte; Deficiency; Mucosa; Rodentia; Gut; B-Lymphocyte; Chemokine receptor; CC chemokine; Cell differentiation; Chemotaxis; Vertebrata; Local immunity; Mammalia; Mouse; Animal; T-Lymphocyte; Homing phenomenon

CC chemokine receptor (CCR) 9, the receptor for the CC-chemokine CCL25/thymus-expressed chemokine (TECK), is mainly expressed by thymocytes and by intraepithelial (IEL) and lamina propria lymphocytes of the small intestine. To study the biologic role of CCR9, a mouse strain was generated in which th...