The Effect of Perinatal High‐Dose Erythropoietin on Retinal Structural and Vascular Characteristics in Children Born Preterm
•Macular vessel density parameters are lower in children who have received EPO compared to placebo.•OCT and OCTA parameters differ between preterm- and term-born children born of comparable age.•The clinical significance of macular structural and vascular differences is yet to be determined. To stud...
Saved in:
Published in | American journal of ophthalmology Vol. 266; pp. 264 - 273 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | •Macular vessel density parameters are lower in children who have received EPO compared to placebo.•OCT and OCTA parameters differ between preterm- and term-born children born of comparable age.•The clinical significance of macular structural and vascular differences is yet to be determined.
To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children.
Randomized, double-blind clinical trial follow-up plus cohort study.
Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
Study Population: extremely or very preterm born children aged 7-15 years from an ongoing neuropediatric study (EpoKids). These had been previously randomized to receive either high-dose rhEPO or placebo perinatally. Inclusion criteria: participation in the EpoKids Study, written informed consent (IC). Exclusion criteria: previous ocular trauma or surgery; retinal or developmental disease unrelated to prematurity. Term-born children of comparable age were enrolled as a healthy control (HC) group. Inclusion criteria: term birth, IC. Exclusion criteria: any ocular or visual abnormality, high refractive error. Examiners were blinded regarding intervention status until completion of all analyses. (Participants/guardians remain blinded).
Observation procedures: Spectral-domain OCT scans (Heidelberg Spectralis system) and OCTA imaging (Zeiss PlexElite 9000) were obtained. Ophthalmological and orthoptic examinations excluded ocular comorbidities.
Main Outcome Measures: OCT (central retinal thickness, CRT; total macular volume, TMV), superficial plexus OCTA (foveal avascular zone, FAZ; vessel density, VD; vessel length density, VLD) parameters and foveal hypoplasia grade according to published criteria.
Macular vessel density parameters (VD and VLD) were significantly lower (p =0.015, CI-95: 0.01 to 0.06 and p=0.015, CI-95: 0.74 to 3.64) in the EPO group (n= 52) when compared to placebo (n=35). No other significant differences were observed between the EPO and placebo group. When comparing the intervention subgroups to HC we found six significant differences in OCT and OCTA parameters (FAZ, VD, VLD and CRT comparing HC and EPO group; FAZ and CRT when comparing HC and placebo group).
Early high-dose rhEPO in infants born extremely or very preterm affects macular vessel density parameters compared to placebo. Premature birth (regardless of intervention status) affects retinal structure and vascular development. Our findings on macular vascular development do not contraindicate the administration of early high-dose EPO in preterm infants. For further understanding of the role of EPO on macular development and its clinical significance, future studies are needed. |
---|---|
AbstractList | To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children.
Randomized, double-blind clinical trial follow-up plus cohort study.
Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
extremely or very preterm born children aged 7-15 years from an ongoing neuropediatric study (EpoKids). These had been previously randomized to receive either high-dose rhEPO or placebo perinatally.
participation in the EpoKids Study, written informed consent (IC).
previous ocular trauma or surgery; retinal or developmental disease unrelated to prematurity. Term-born children of comparable age were enrolled as a healthy control (HC) group.
term birth, IC.
any ocular or visual abnormality, high refractive error. Examiners were blinded regarding intervention status until completion of all analyses. (Participants/guardians remain blinded).
Spectral-domain OCT scans (Heidelberg Spectralis system) and OCTA imaging (Zeiss PlexElite 9000) were obtained. Ophthalmological and orthoptic examinations excluded ocular comorbidities.
OCT (central retinal thickness, CRT; total macular volume, TMV), superficial plexus OCTA (foveal avascular zone, FAZ; vessel density, VD; vessel length density, VLD) parameters and foveal hypoplasia grade according to published criteria.
Macular vessel density parameters (VD and VLD) were significantly lower (p =0.015, CI-95: 0.01 to 0.06 and p=0.015, CI-95: 0.74 to 3.64) in the EPO group (n= 52) when compared to placebo (n=35). No other significant differences were observed between the EPO and placebo group. When comparing the intervention subgroups to HC we found six significant differences in OCT and OCTA parameters (FAZ, VD, VLD and CRT comparing HC and EPO group; FAZ and CRT when comparing HC and placebo group).
Early high-dose rhEPO in infants born extremely or very preterm affects macular vessel density parameters compared to placebo. Premature birth (regardless of intervention status) affects retinal structure and vascular development. Our findings on macular vascular development do not contraindicate the administration of early high-dose EPO in preterm infants. For further understanding of the role of EPO on macular development and its clinical significance, future studies are needed. •Macular vessel density parameters are lower in children who have received EPO compared to placebo.•OCT and OCTA parameters differ between preterm- and term-born children born of comparable age.•The clinical significance of macular structural and vascular differences is yet to be determined. To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children. Randomized, double-blind clinical trial follow-up plus cohort study. Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland. Study Population: extremely or very preterm born children aged 7-15 years from an ongoing neuropediatric study (EpoKids). These had been previously randomized to receive either high-dose rhEPO or placebo perinatally. Inclusion criteria: participation in the EpoKids Study, written informed consent (IC). Exclusion criteria: previous ocular trauma or surgery; retinal or developmental disease unrelated to prematurity. Term-born children of comparable age were enrolled as a healthy control (HC) group. Inclusion criteria: term birth, IC. Exclusion criteria: any ocular or visual abnormality, high refractive error. Examiners were blinded regarding intervention status until completion of all analyses. (Participants/guardians remain blinded). Observation procedures: Spectral-domain OCT scans (Heidelberg Spectralis system) and OCTA imaging (Zeiss PlexElite 9000) were obtained. Ophthalmological and orthoptic examinations excluded ocular comorbidities. Main Outcome Measures: OCT (central retinal thickness, CRT; total macular volume, TMV), superficial plexus OCTA (foveal avascular zone, FAZ; vessel density, VD; vessel length density, VLD) parameters and foveal hypoplasia grade according to published criteria. Macular vessel density parameters (VD and VLD) were significantly lower (p =0.015, CI-95: 0.01 to 0.06 and p=0.015, CI-95: 0.74 to 3.64) in the EPO group (n= 52) when compared to placebo (n=35). No other significant differences were observed between the EPO and placebo group. When comparing the intervention subgroups to HC we found six significant differences in OCT and OCTA parameters (FAZ, VD, VLD and CRT comparing HC and EPO group; FAZ and CRT when comparing HC and placebo group). Early high-dose rhEPO in infants born extremely or very preterm affects macular vessel density parameters compared to placebo. Premature birth (regardless of intervention status) affects retinal structure and vascular development. Our findings on macular vascular development do not contraindicate the administration of early high-dose EPO in preterm infants. For further understanding of the role of EPO on macular development and its clinical significance, future studies are needed. To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children.PURPOSETo study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children.Randomized, double-blind clinical trial follow-up plus cohort study.DESIGNRandomized, double-blind clinical trial follow-up plus cohort study.Setting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.METHODSSetting: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.extremely or very preterm born children aged 7-15 years from an ongoing neuropediatric study (EpoKids). These had been previously randomized to receive either high-dose rhEPO or placebo perinatally.STUDY POPULATIONextremely or very preterm born children aged 7-15 years from an ongoing neuropediatric study (EpoKids). These had been previously randomized to receive either high-dose rhEPO or placebo perinatally.participation in the EpoKids Study, written informed consent (IC).INCLUSION CRITERIAparticipation in the EpoKids Study, written informed consent (IC).previous ocular trauma or surgery; retinal or developmental disease unrelated to prematurity. Term-born children of comparable age were enrolled as a healthy control (HC) group.EXCLUSION CRITERIAprevious ocular trauma or surgery; retinal or developmental disease unrelated to prematurity. Term-born children of comparable age were enrolled as a healthy control (HC) group.term birth, IC.INCLUSION CRITERIAterm birth, IC.any ocular or visual abnormality, high refractive error. Examiners were blinded regarding intervention status until completion of all analyses. (Participants/guardians remain blinded).EXCLUSION CRITERIAany ocular or visual abnormality, high refractive error. Examiners were blinded regarding intervention status until completion of all analyses. (Participants/guardians remain blinded).Spectral-domain OCT scans (Heidelberg Spectralis system) and OCTA imaging (Zeiss PlexElite 9000) were obtained. Ophthalmological and orthoptic examinations excluded ocular comorbidities.OBSERVATION PROCEDURESSpectral-domain OCT scans (Heidelberg Spectralis system) and OCTA imaging (Zeiss PlexElite 9000) were obtained. Ophthalmological and orthoptic examinations excluded ocular comorbidities.OCT (central retinal thickness, CRT; total macular volume, TMV), superficial plexus OCTA (foveal avascular zone, FAZ; vessel density, VD; vessel length density, VLD) parameters and foveal hypoplasia grade according to published criteria.MAIN OUTCOME MEASURESOCT (central retinal thickness, CRT; total macular volume, TMV), superficial plexus OCTA (foveal avascular zone, FAZ; vessel density, VD; vessel length density, VLD) parameters and foveal hypoplasia grade according to published criteria.Macular vessel density parameters (VD and VLD) were significantly lower (p =0.015, CI-95: 0.01 to 0.06 and p=0.015, CI-95: 0.74 to 3.64) in the EPO group (n= 52) when compared to placebo (n=35). No other significant differences were observed between the EPO and placebo group. When comparing the intervention subgroups to HC we found six significant differences in OCT and OCTA parameters (FAZ, VD, VLD and CRT comparing HC and EPO group; FAZ and CRT when comparing HC and placebo group).RESULTSMacular vessel density parameters (VD and VLD) were significantly lower (p =0.015, CI-95: 0.01 to 0.06 and p=0.015, CI-95: 0.74 to 3.64) in the EPO group (n= 52) when compared to placebo (n=35). No other significant differences were observed between the EPO and placebo group. When comparing the intervention subgroups to HC we found six significant differences in OCT and OCTA parameters (FAZ, VD, VLD and CRT comparing HC and EPO group; FAZ and CRT when comparing HC and placebo group).Early high-dose rhEPO in infants born extremely or very preterm affects macular vessel density parameters compared to placebo. Premature birth (regardless of intervention status) affects retinal structure and vascular development. Our findings on macular vascular development do not contraindicate the administration of early high-dose EPO in preterm infants. For further understanding of the role of EPO on macular development and its clinical significance, future studies are needed.CONCLUSIONSEarly high-dose rhEPO in infants born extremely or very preterm affects macular vessel density parameters compared to placebo. Premature birth (regardless of intervention status) affects retinal structure and vascular development. Our findings on macular vascular development do not contraindicate the administration of early high-dose EPO in preterm infants. For further understanding of the role of EPO on macular development and its clinical significance, future studies are needed. |
Author | Wehrle, Flavia M. Fauchère, Jean-Claude Gerth-Kahlert, Christina Hagmann, Cornelia F. Heyard, Rachel Hanson, James V.M. Sisera, Lorena Füglistaler, Jonas Jeltsch, Brida M. |
Author_xml | – sequence: 1 givenname: Brida M. orcidid: 0000-0001-8226-7742 surname: Jeltsch fullname: Jeltsch, Brida M. organization: From the Department of Ophthalmology (B.M.J., J.V.M.H., L.S., C.G-K.), University Hospital Zurich and University of Zurich, Zurich, Switzerland – sequence: 2 givenname: James V.M. surname: Hanson fullname: Hanson, James V.M. organization: From the Department of Ophthalmology (B.M.J., J.V.M.H., L.S., C.G-K.), University Hospital Zurich and University of Zurich, Zurich, Switzerland – sequence: 3 givenname: Jonas orcidid: 0009-0007-0735-4505 surname: Füglistaler fullname: Füglistaler, Jonas organization: Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute (J.F., R.H.), University of Zurich, Zurich, Switzerland – sequence: 4 givenname: Rachel orcidid: 0000-0002-7531-4333 surname: Heyard fullname: Heyard, Rachel organization: Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute (J.F., R.H.), University of Zurich, Zurich, Switzerland – sequence: 5 givenname: Lorena surname: Sisera fullname: Sisera, Lorena organization: From the Department of Ophthalmology (B.M.J., J.V.M.H., L.S., C.G-K.), University Hospital Zurich and University of Zurich, Zurich, Switzerland – sequence: 6 givenname: Flavia M. orcidid: 0000-0001-5992-0424 surname: Wehrle fullname: Wehrle, Flavia M. organization: Department of Neonatology and Pediatric Intensive Care (F.M.W., C.F.H), University Children's Hospital Zurich, Zurich, Switzerland – sequence: 7 givenname: Cornelia F. surname: Hagmann fullname: Hagmann, Cornelia F. organization: Department of Neonatology and Pediatric Intensive Care (F.M.W., C.F.H), University Children's Hospital Zurich, Zurich, Switzerland – sequence: 8 givenname: Jean-Claude surname: Fauchère fullname: Fauchère, Jean-Claude organization: Department of Neonatology (J-C.F.), University Hospital Zurich and University of Zurich, Zurich, Switzerland – sequence: 9 givenname: Christina orcidid: 0000-0001-6298-615X surname: Gerth-Kahlert fullname: Gerth-Kahlert, Christina email: Christina.gerth-kahlert@usz.ch organization: From the Department of Ophthalmology (B.M.J., J.V.M.H., L.S., C.G-K.), University Hospital Zurich and University of Zurich, Zurich, Switzerland |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38880371$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kMtuEzEUhi1URNPCA7BBXrKZwZdk7BErCL1JlVpBYWt57GPG0cQOtgepG8Qj9Bl5EhylZcnKxz7f_0v-TtBRiAEQek1JSwnt3m1avYktI2zZkq4lZPUMLagUfUNlT4_QghDCmp73y2N0kvOmXjuxFC_QMZdSEi7oAv26GwGfOQem4OjwLSQfdNETvvTfxz-_Hz7FXPfpvowp7qKH4gOOAX_eD5X6UtJsypzqqIPF33Q286QTXo86aVNqWy7eZFxT69FPNkHAH2MK-DZB3W5foudOTxlePZ6n6Ov52d36srm-ubhaf7huDBOyNIPjRkgr2EoLJgwVzAwropeuZ5ZJ2hPb01V9lIY7ECBhGGw3AOXg9KCF46fo7aF3l-KPGXJRW58NTJMOEOesOOn62ko6XlF6QE2KOSdwapf8Vqd7RYnaa1cbVbWrvXZFOlW118ybx_p52IL9l3jyXIH3BwDqJ396SCobD8GA9amqVzb6_9T_BQUWl-A |
Cites_doi | 10.1016/j.critrevonc.2007.03.001 10.1152/ajpregu.00108.2010 10.1007/s00417-017-3662-5 10.1016/j.preteyeres.2017.11.001 10.1001/jama.2014.9645 10.1038/eye.2009.324 10.1136/archdischild-2017-313574 10.1083/jcb.200302047 10.1159/000511262 10.1038/s41433-019-0500-5 10.1007/s12020-011-9579-6 10.1002/jnr.22046 10.1016/j.ajo.2012.05.004 10.1136/bmjopen-2018-022157 10.1056/NEJMoa1907423 10.1007/s00417-018-4162-y 10.1167/iovs.08-2521 10.1093/biomet/73.1.13 10.1016/j.oret.2018.02.004 10.1016/j.jpeds.2015.02.052 10.1016/j.tree.2021.10.009 10.1001/jama.2016.5504 10.1097/IAE.0000000000001471 10.1111/j.1365-2141.1992.tb08200.x 10.1007/s00592-017-0996-8 10.1007/s00417-021-05090-7 10.1016/j.ophtha.2011.01.028 10.1016/j.ajo.2020.06.001 10.1136/bjophthalmol-2012-301612 10.1007/s10571-007-9155-z 10.1167/iovs.13-11625 10.1167/iovs.15-18843 10.1056/NEJMoa1605566 10.1016/j.jaapos.2007.08.009 10.1016/j.ophtha.2011.05.028 10.1093/brain/awu363 10.1016/j.jaapos.2008.02.001 10.1016/j.freeradbiomed.2008.11.027 10.1002/ana.21977 10.1097/IAE.0000000000001937 10.1093/biomet/75.4.800 10.1097/IAE.0000000000003501 10.1084/jem.20021067 10.1097/IAE.0000000000002301 |
ContentType | Journal Article |
Copyright | 2024 The Author(s) Copyright © 2024. Published by Elsevier Inc. Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2024 The Author(s) – notice: Copyright © 2024. Published by Elsevier Inc. – notice: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. |
DBID | 6I. AAFTH NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.ajo.2024.06.005 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1879-1891 |
EndPage | 273 |
ExternalDocumentID | 10_1016_j_ajo_2024_06_005 38880371 S0002939424002423 |
Genre | Journal Article |
GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .~1 0R~ 1B1 1CY 1P~ 1~. 1~5 23M 3V. 4.4 457 4G. 53G 5GY 5RE 5VS 6I. 6J9 7-5 71M 7RV 7X7 8FI 8P~ AABNK AACTN AAEDT AAEDW AAFTH AAHTB AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAWTL AAXKI AAXUO ABBQC ABCQX ABFNM ABFRF ABJNI ABLJU ABMAC ABMZM ABOCM ABPEJ ABXDB ACDAQ ACGFO ACGFS ACIUM ACNCT ACRLP ADBBV ADEZE ADFRT ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFKRA AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHMBA AI. AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN AZQEC BENPR BKEYQ BKOJK BLXMC BNPGV BPHCQ BVXVI CS3 EBS EFJIC EJD EMOBN EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-Q G8K GBLVA GUQSH HVGLF HZ~ IHE J1W J5H K-O KOM L7B M1P M2O M41 MO0 N4W N9A O-L O9- OAUVE OF- OPF OQ~ OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SEL SES SPCBC SSH SSZ SV3 T5K UNMZH UV1 VH1 WH7 WOW X7M XPP Z5R ZGI ZXP ~G- AFJKZ NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c278t-bf3c78d725a727c172cb50a4f92d28190d91572c8c3fe7e8ebbd6be13efaba7f3 |
IEDL.DBID | AIKHN |
ISSN | 0002-9394 1879-1891 |
IngestDate | Sat Oct 05 17:03:38 EDT 2024 Thu Sep 26 20:23:40 EDT 2024 Wed Oct 23 10:03:12 EDT 2024 Sat Sep 14 18:05:49 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | preterm birth retinal development retina optical coherence tomography angiography erythropoietin |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. Copyright © 2024. Published by Elsevier Inc. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c278t-bf3c78d725a727c172cb50a4f92d28190d91572c8c3fe7e8ebbd6be13efaba7f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
ORCID | 0009-0007-0735-4505 0000-0002-7531-4333 0000-0001-5992-0424 0000-0001-6298-615X 0000-0001-8226-7742 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0002939424002423 |
PMID | 38880371 |
PQID | 3069172063 |
PQPubID | 23479 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_3069172063 crossref_primary_10_1016_j_ajo_2024_06_005 pubmed_primary_38880371 elsevier_sciencedirect_doi_10_1016_j_ajo_2024_06_005 |
PublicationCentury | 2000 |
PublicationDate | 2024-10-01 |
PublicationDateYYYYMMDD | 2024-10-01 |
PublicationDate_xml | – month: 10 year: 2024 text: 2024-10-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | American journal of ophthalmology |
PublicationTitleAlternate | Am J Ophthalmol |
PublicationYear | 2024 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | McCloskey, Wang, Jiang, Smith, Strange, Hartnett (bib0049) 2013; 54 Fu, Wu, Wang, Li, Lee, So (bib0014) 2008; 28 Fiess, Pfisterer, Gissler (bib0038) 2022; 42 Juul, Comstock, Wadhawan (bib0021) 2020; 382 Chen, Connor, Aderman, Smith (bib0024) 2008; 118 Wehrle, Held, O'Gorman (bib0030) 2018; 8 Gariano (bib0007) 2010; 24 Suk, Dunbar, Liu (bib0017) 2008; 12 Fauchere, Koller, Tschopp (bib0028) 2015; 167 Selvam, Kumar, Fruttiger (bib0047) 2018; 63 Aher, Ohlsson (bib0026) 2020; 2 Fiess, Janz, Schuster (bib0039) 2017; 255 Bowl, Bowl, Schweinfurth (bib0003) 2018; 2 Gerull, Brauer, Bassler (bib0050) 2018; 103 Natalucci, Latal, Koller (bib0020) 2016; 315 Hochberg (bib0035) 1988; 75 . Chen, Connor, Aderman, Willett, Aspegren, Smith (bib0046) 2009; 50 Falavarjani, Iafe, Velez (bib0009) 2017; 37 Ohlsson, Aher (bib0027) 2020; 2 Muff, Nilsen, O'Hara, Nater (bib0036) 2022; 37 Noguchi, Asavaritikrai, Teng, Jia (bib0013) 2007; 64 Villa, Bigini, Mennini (bib0016) 2003; 198 Liang, Scott (bib0034) 1986; 73 Chung, Lee, Lamoke, Hrushesky, Wood, Jahng (bib0023) 2009; 87 Carnevali, Sacconi, Corbelli (bib0033) 2017; 54 Vajzovic, Hendrickson, O'Connell (bib0004) 2012; 154 Balasubramanian, Borrelli, Lonngi (bib0011) 2019; 39 World Health Organization. Preterm birth. World Health Organization. Accessed March 11, 2023. Nonobe, Kaneko, Ito (bib0044) 2019; 39 Miki, Yamada, Nakamura (bib0040) 2019; 2019 Scheerer, Dunker, Imagawa, Yamamoto, Suzuki, Fandrey (bib0015) 2010; 299 Thomas, Kumar, Mohammad (bib0032) 2011; 118 Neubauer, Voss, Wachtendorf, Jungmann (bib0018) 2010; 67 O'Gorman, Bucher, Held (bib0019) 2015; 138 Gerhardt, Golding, Fruttiger (bib0048) 2003; 161 Schuster, Koury, Bohrer, Salceda, Caro (bib0012) 1992; 81 Mayock, Xie, Comstock, Heagerty, Juul (bib0029) 2020; 117 Chen, Smith (bib0045) 2008; 12 Vinekar, Sinha, Mangalesh, Jayadev, Shetty (bib0042) 2021; 259 Chen, Chen, Chen (bib0041) 2019; 257 Takagi, Maruko, Yamaguchi, Kakehashi, Hasegawa, Iida (bib0043) 2019; 33 Younge, Goldstein, Bann (bib0002) 2017; 376 Bowl, Stieger, Bokun (bib0005) 2016; 57 Yanni, Wang, Chan (bib0008) 2012; 96 Wang, Shen, Tu (bib0022) 2009; 46 (bib0037) 2022 Leuchter, Gui, Poncet (bib0031) 2014; 312 Hernandez, Simo (bib0025) 2012; 41 Maldonado, O'Connell, Sarin (bib0006) 2011; 118 Tiryaki Demir, Bas, Karapapak (bib0010) 2020; 219 Vajzovic (10.1016/j.ajo.2024.06.005_bib0004) 2012; 154 Chen (10.1016/j.ajo.2024.06.005_bib0041) 2019; 257 Wehrle (10.1016/j.ajo.2024.06.005_bib0030) 2018; 8 Scheerer (10.1016/j.ajo.2024.06.005_bib0015) 2010; 299 Chen (10.1016/j.ajo.2024.06.005_bib0024) 2008; 118 Hochberg (10.1016/j.ajo.2024.06.005_bib0035) 1988; 75 Muff (10.1016/j.ajo.2024.06.005_bib0036) 2022; 37 Fauchere (10.1016/j.ajo.2024.06.005_bib0028) 2015; 167 Falavarjani (10.1016/j.ajo.2024.06.005_bib0009) 2017; 37 Noguchi (10.1016/j.ajo.2024.06.005_bib0013) 2007; 64 Maldonado (10.1016/j.ajo.2024.06.005_bib0006) 2011; 118 Leuchter (10.1016/j.ajo.2024.06.005_bib0031) 2014; 312 Vinekar (10.1016/j.ajo.2024.06.005_bib0042) 2021; 259 Selvam (10.1016/j.ajo.2024.06.005_bib0047) 2018; 63 Fu (10.1016/j.ajo.2024.06.005_bib0014) 2008; 28 Bowl (10.1016/j.ajo.2024.06.005_bib0003) 2018; 2 Chen (10.1016/j.ajo.2024.06.005_bib0046) 2009; 50 10.1016/j.ajo.2024.06.005_bib0001 Aher (10.1016/j.ajo.2024.06.005_bib0026) 2020; 2 Schuster (10.1016/j.ajo.2024.06.005_bib0012) 1992; 81 Fiess (10.1016/j.ajo.2024.06.005_bib0039) 2017; 255 Gerhardt (10.1016/j.ajo.2024.06.005_bib0048) 2003; 161 Carnevali (10.1016/j.ajo.2024.06.005_bib0033) 2017; 54 Liang (10.1016/j.ajo.2024.06.005_bib0034) 1986; 73 Chung (10.1016/j.ajo.2024.06.005_bib0023) 2009; 87 Gerull (10.1016/j.ajo.2024.06.005_bib0050) 2018; 103 Nonobe (10.1016/j.ajo.2024.06.005_bib0044) 2019; 39 Neubauer (10.1016/j.ajo.2024.06.005_bib0018) 2010; 67 Fiess (10.1016/j.ajo.2024.06.005_bib0038) 2022; 42 Juul (10.1016/j.ajo.2024.06.005_bib0021) 2020; 382 (10.1016/j.ajo.2024.06.005_bib0037) 2022 Yanni (10.1016/j.ajo.2024.06.005_bib0008) 2012; 96 Tiryaki Demir (10.1016/j.ajo.2024.06.005_bib0010) 2020; 219 Wang (10.1016/j.ajo.2024.06.005_bib0022) 2009; 46 Bowl (10.1016/j.ajo.2024.06.005_bib0005) 2016; 57 Mayock (10.1016/j.ajo.2024.06.005_bib0029) 2020; 117 Younge (10.1016/j.ajo.2024.06.005_bib0002) 2017; 376 Gariano (10.1016/j.ajo.2024.06.005_bib0007) 2010; 24 Ohlsson (10.1016/j.ajo.2024.06.005_bib0027) 2020; 2 Miki (10.1016/j.ajo.2024.06.005_bib0040) 2019; 2019 Balasubramanian (10.1016/j.ajo.2024.06.005_bib0011) 2019; 39 O'Gorman (10.1016/j.ajo.2024.06.005_bib0019) 2015; 138 Chen (10.1016/j.ajo.2024.06.005_bib0045) 2008; 12 Villa (10.1016/j.ajo.2024.06.005_bib0016) 2003; 198 Suk (10.1016/j.ajo.2024.06.005_bib0017) 2008; 12 Natalucci (10.1016/j.ajo.2024.06.005_bib0020) 2016; 315 Thomas (10.1016/j.ajo.2024.06.005_bib0032) 2011; 118 McCloskey (10.1016/j.ajo.2024.06.005_bib0049) 2013; 54 Takagi (10.1016/j.ajo.2024.06.005_bib0043) 2019; 33 Hernandez (10.1016/j.ajo.2024.06.005_bib0025) 2012; 41 |
References_xml | – volume: 312 start-page: 817 year: 2014 end-page: 824 ident: bib0031 article-title: Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age publication-title: JAMA contributor: fullname: Poncet – volume: 154 start-page: 779 year: 2012 end-page: 789 ident: bib0004 article-title: Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology publication-title: Am J Ophthalmol contributor: fullname: O'Connell – volume: 28 start-page: 317 year: 2008 end-page: 329 ident: bib0014 article-title: Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension publication-title: Cell Mol Neurobiol contributor: fullname: So – volume: 33 start-page: 1890 year: 2019 end-page: 1896 ident: bib0043 article-title: Foveal abnormalities determined by optical coherence tomography angiography in children with history of retinopathy of prematurity publication-title: Eye (Lond) contributor: fullname: Iida – volume: 118 start-page: 2315 year: 2011 end-page: 2325 ident: bib0006 article-title: Dynamics of human foveal development after premature birth publication-title: Ophthalmology contributor: fullname: Sarin – volume: 12 start-page: 233 year: 2008 end-page: 238 ident: bib0017 article-title: Human recombinant erythropoietin and the incidence of retinopathy of prematurity: a multiple regression model publication-title: J AAPOS contributor: fullname: Liu – volume: 42 start-page: 1716 year: 2022 end-page: 1728 ident: bib0038 article-title: Retinal thickness and foveal hypoplasia in adults born preterm with and without retinopathy of prematurity: the Gutenberg Prematurity Eye Study publication-title: Retina contributor: fullname: Gissler – year: 2022 ident: bib0037 article-title: R: A Language and Environment for Statistical Computing – volume: 198 start-page: 971 year: 2003 end-page: 975 ident: bib0016 article-title: Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis publication-title: J Exp Med contributor: fullname: Mennini – volume: 57 start-page: OCT235 year: 2016 end-page: OCT241 ident: bib0005 article-title: OCT-based macular structure-function correlation in dependence on birth weight and gestational age-the giessen long-term ROP study publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Bokun – volume: 54 start-page: 2020 year: 2013 end-page: 2026 ident: bib0049 article-title: Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity publication-title: Invest Ophthalmol Vis Sci. contributor: fullname: Hartnett – volume: 96 start-page: 961 year: 2012 end-page: 966 ident: bib0008 article-title: Foveal avascular zone and foveal pit formation after preterm birth publication-title: Br J Ophthalmol contributor: fullname: Chan – volume: 54 start-page: 695 year: 2017 end-page: 702 ident: bib0033 article-title: Optical coherence tomography angiography analysis of retinal vascular plexuses and choriocapillaris in patients with type 1 diabetes without diabetic retinopathy publication-title: Acta Diabetol contributor: fullname: Corbelli – volume: 8 year: 2018 ident: bib0030 article-title: Long-term neuroprotective effect of erythropoietin on executive functions in very preterm children (EpoKids): protocol of a prospective follow-up study publication-title: BMJ Open contributor: fullname: O'Gorman – volume: 63 start-page: 1 year: 2018 end-page: 19 ident: bib0047 article-title: Retinal vasculature development in health and disease publication-title: Prog Retin Eye Res. contributor: fullname: Fruttiger – volume: 81 start-page: 153 year: 1992 end-page: 159 ident: bib0012 article-title: Cellular sites of extrarenal and renal erythropoietin production in anaemic rats publication-title: Br J Haematol contributor: fullname: Caro – volume: 73 start-page: 13 year: 1986 end-page: 22 ident: bib0034 article-title: Longitudinal data analysis using generalized linear models publication-title: Biometrika contributor: fullname: Scott – volume: 299 start-page: R111 year: 2010 end-page: R118 ident: bib0015 article-title: The anemia of the newborn induces erythropoietin expression in the developing mouse retina publication-title: Am J Physiol Regul Integr Comp Physiol contributor: fullname: Fandrey – volume: 2 start-page: 972 year: 2018 end-page: 978 ident: bib0003 article-title: OCT angiography in young children with a history of retinopathy of prematurity publication-title: Ophthalmol Retina contributor: fullname: Schweinfurth – volume: 138 start-page: 388 year: 2015 end-page: 397 ident: bib0019 article-title: Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants publication-title: Brain contributor: fullname: Held – volume: 315 start-page: 2079 year: 2016 end-page: 2085 ident: bib0020 article-title: Effect of early prophylactic high-dose recombinant human erythropoietin in very preterm infants on neurodevelopmental outcome at 2 years: a randomized clinical trial publication-title: JAMA contributor: fullname: Koller – volume: 39 start-page: 111 year: 2019 end-page: 117 ident: bib0044 article-title: Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity publication-title: Retina contributor: fullname: Ito – volume: 257 start-page: 23 year: 2019 end-page: 30 ident: bib0041 article-title: Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity publication-title: Graefes Arch Clin Exp Ophthalmol contributor: fullname: Chen – volume: 382 start-page: 233 year: 2020 end-page: 243 ident: bib0021 article-title: A randomized trial of erythropoietin for neuroprotection in preterm infants publication-title: N Engl J Med contributor: fullname: Wadhawan – volume: 118 start-page: 526 year: 2008 end-page: 533 ident: bib0024 article-title: Erythropoietin deficiency decreases vascular stability in mice publication-title: J Clin Invest contributor: fullname: Smith – volume: 167 start-page: 52 year: 2015 end-page: 57 ident: bib0028 article-title: Safety of early high-dose recombinant erythropoietin for neuroprotection in very preterm infants publication-title: J Pediatr contributor: fullname: Tschopp – volume: 12 start-page: 221 year: 2008 end-page: 222 ident: bib0045 article-title: A double-edged sword: erythropoietin eyed in retinopathy of prematurity publication-title: J AAPOS contributor: fullname: Smith – volume: 2019 year: 2019 ident: bib0040 article-title: The size of the foveal avascular zone is associated with foveal thickness and structure in premature children publication-title: J Ophthalmol contributor: fullname: Nakamura – volume: 103 start-page: F337 year: 2018 end-page: F342 ident: bib0050 article-title: Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006-2015: a population-based analysis publication-title: Arch Dis Child Fetal Neonatal Ed. contributor: fullname: Bassler – volume: 75 start-page: 800 year: 1988 end-page: 802 ident: bib0035 article-title: A sharper bonferroni procedure for multiple tests of significance publication-title: Biometrika contributor: fullname: Hochberg – volume: 41 start-page: 220 year: 2012 end-page: 226 ident: bib0025 article-title: Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy publication-title: Endocrine contributor: fullname: Simo – volume: 50 start-page: 1329 year: 2009 end-page: 1335 ident: bib0046 article-title: Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy publication-title: Invest Ophthalmol Vis Sci. contributor: fullname: Smith – volume: 46 start-page: 1032 year: 2009 end-page: 1041 ident: bib0022 article-title: Erythropoietin protects retinal pigment epithelial cells from oxidative damage publication-title: Free Radic Biol Med contributor: fullname: Tu – volume: 67 start-page: 657 year: 2010 end-page: 666 ident: bib0018 article-title: Erythropoietin improves neurodevelopmental outcome of extremely preterm infants publication-title: Ann Neurol contributor: fullname: Jungmann – volume: 255 start-page: 1433 year: 2017 end-page: 1442 ident: bib0039 article-title: Macular morphology in former preterm and full-term infants aged 4 to 10 years publication-title: Graefes Arch Clin Exp Ophthalmol contributor: fullname: Schuster – volume: 64 start-page: 159 year: 2007 end-page: 171 ident: bib0013 article-title: Role of erythropoietin in the brain publication-title: Crit Rev Oncol Hematol contributor: fullname: Jia – volume: 37 start-page: 203 year: 2022 end-page: 210 ident: bib0036 article-title: Rewriting results sections in the language of evidence publication-title: Trends Ecol Evol contributor: fullname: Nater – volume: 37 start-page: 2289 year: 2017 end-page: 2294 ident: bib0009 article-title: Optical coherence tomography angiography of the fovea in children born preterm publication-title: Retina contributor: fullname: Velez – volume: 259 start-page: 2131 year: 2021 end-page: 2137 ident: bib0042 article-title: Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity publication-title: Graefes Arch Clin Exp Ophthalmol contributor: fullname: Shetty – volume: 87 start-page: 2365 year: 2009 end-page: 2374 ident: bib0023 article-title: Neuroprotective role of erythropoietin by antiapoptosis in the retina publication-title: J Neurosci Res contributor: fullname: Jahng – volume: 376 start-page: 617 year: 2017 end-page: 628 ident: bib0002 article-title: Survival and neurodevelopmental outcomes among periviable infants publication-title: N Engl J Med contributor: fullname: Bann – volume: 117 start-page: 650 year: 2020 end-page: 657 ident: bib0029 article-title: High-dose erythropoietin in extremely low gestational age neonates does not alter risk of retinopathy of prematurity publication-title: Neonatology contributor: fullname: Juul – volume: 2 year: 2020 ident: bib0026 article-title: Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants publication-title: Cochrane Database Syst Rev contributor: fullname: Ohlsson – volume: 2 year: 2020 ident: bib0027 article-title: Early erythropoiesis-stimulating agents in preterm or low birth weight infants publication-title: Cochrane Database Syst Rev contributor: fullname: Aher – volume: 39 start-page: 2233 year: 2019 end-page: 2239 ident: bib0011 article-title: Visual function and optical coherence tomography angiography features in children born preterm publication-title: Retina contributor: fullname: Lonngi – volume: 161 start-page: 1163 year: 2003 end-page: 1177 ident: bib0048 article-title: VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia publication-title: J Cell Biol contributor: fullname: Fruttiger – volume: 24 start-page: 401 year: 2010 end-page: 407 ident: bib0007 article-title: Special features of human retinal angiogenesis publication-title: Eye (Lond) contributor: fullname: Gariano – volume: 219 start-page: 177 year: 2020 end-page: 185 ident: bib0010 article-title: Effect of prematurity on foveal development in early school-age children publication-title: Am J Ophthalmol contributor: fullname: Karapapak – volume: 118 start-page: 1653 year: 2011 end-page: 1660 ident: bib0032 article-title: Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity? publication-title: Ophthalmology contributor: fullname: Mohammad – volume: 64 start-page: 159 issue: 2 year: 2007 ident: 10.1016/j.ajo.2024.06.005_bib0013 article-title: Role of erythropoietin in the brain publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2007.03.001 contributor: fullname: Noguchi – ident: 10.1016/j.ajo.2024.06.005_bib0001 – volume: 299 start-page: R111 issue: 1 year: 2010 ident: 10.1016/j.ajo.2024.06.005_bib0015 article-title: The anemia of the newborn induces erythropoietin expression in the developing mouse retina publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00108.2010 contributor: fullname: Scheerer – volume: 255 start-page: 1433 issue: 7 year: 2017 ident: 10.1016/j.ajo.2024.06.005_bib0039 article-title: Macular morphology in former preterm and full-term infants aged 4 to 10 years publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-017-3662-5 contributor: fullname: Fiess – volume: 63 start-page: 1 year: 2018 ident: 10.1016/j.ajo.2024.06.005_bib0047 article-title: Retinal vasculature development in health and disease publication-title: Prog Retin Eye Res. doi: 10.1016/j.preteyeres.2017.11.001 contributor: fullname: Selvam – volume: 312 start-page: 817 issue: 8 year: 2014 ident: 10.1016/j.ajo.2024.06.005_bib0031 article-title: Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age publication-title: JAMA doi: 10.1001/jama.2014.9645 contributor: fullname: Leuchter – volume: 2019 year: 2019 ident: 10.1016/j.ajo.2024.06.005_bib0040 article-title: The size of the foveal avascular zone is associated with foveal thickness and structure in premature children publication-title: J Ophthalmol contributor: fullname: Miki – volume: 24 start-page: 401 issue: 3 year: 2010 ident: 10.1016/j.ajo.2024.06.005_bib0007 article-title: Special features of human retinal angiogenesis publication-title: Eye (Lond) doi: 10.1038/eye.2009.324 contributor: fullname: Gariano – volume: 103 start-page: F337 issue: 4 year: 2018 ident: 10.1016/j.ajo.2024.06.005_bib0050 article-title: Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006-2015: a population-based analysis publication-title: Arch Dis Child Fetal Neonatal Ed. doi: 10.1136/archdischild-2017-313574 contributor: fullname: Gerull – volume: 161 start-page: 1163 issue: 6 year: 2003 ident: 10.1016/j.ajo.2024.06.005_bib0048 article-title: VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia publication-title: J Cell Biol doi: 10.1083/jcb.200302047 contributor: fullname: Gerhardt – volume: 117 start-page: 650 issue: 5 year: 2020 ident: 10.1016/j.ajo.2024.06.005_bib0029 article-title: High-dose erythropoietin in extremely low gestational age neonates does not alter risk of retinopathy of prematurity publication-title: Neonatology doi: 10.1159/000511262 contributor: fullname: Mayock – volume: 33 start-page: 1890 issue: 12 year: 2019 ident: 10.1016/j.ajo.2024.06.005_bib0043 article-title: Foveal abnormalities determined by optical coherence tomography angiography in children with history of retinopathy of prematurity publication-title: Eye (Lond) doi: 10.1038/s41433-019-0500-5 contributor: fullname: Takagi – volume: 41 start-page: 220 issue: 2 year: 2012 ident: 10.1016/j.ajo.2024.06.005_bib0025 article-title: Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy publication-title: Endocrine doi: 10.1007/s12020-011-9579-6 contributor: fullname: Hernandez – year: 2022 ident: 10.1016/j.ajo.2024.06.005_bib0037 – volume: 118 start-page: 526 issue: 2 year: 2008 ident: 10.1016/j.ajo.2024.06.005_bib0024 article-title: Erythropoietin deficiency decreases vascular stability in mice publication-title: J Clin Invest contributor: fullname: Chen – volume: 87 start-page: 2365 issue: 10 year: 2009 ident: 10.1016/j.ajo.2024.06.005_bib0023 article-title: Neuroprotective role of erythropoietin by antiapoptosis in the retina publication-title: J Neurosci Res doi: 10.1002/jnr.22046 contributor: fullname: Chung – volume: 154 start-page: 779 issue: 5 year: 2012 ident: 10.1016/j.ajo.2024.06.005_bib0004 article-title: Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2012.05.004 contributor: fullname: Vajzovic – volume: 8 issue: 4 year: 2018 ident: 10.1016/j.ajo.2024.06.005_bib0030 article-title: Long-term neuroprotective effect of erythropoietin on executive functions in very preterm children (EpoKids): protocol of a prospective follow-up study publication-title: BMJ Open doi: 10.1136/bmjopen-2018-022157 contributor: fullname: Wehrle – volume: 382 start-page: 233 issue: 3 year: 2020 ident: 10.1016/j.ajo.2024.06.005_bib0021 article-title: A randomized trial of erythropoietin for neuroprotection in preterm infants publication-title: N Engl J Med doi: 10.1056/NEJMoa1907423 contributor: fullname: Juul – volume: 257 start-page: 23 issue: 1 year: 2019 ident: 10.1016/j.ajo.2024.06.005_bib0041 article-title: Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-018-4162-y contributor: fullname: Chen – volume: 50 start-page: 1329 issue: 3 year: 2009 ident: 10.1016/j.ajo.2024.06.005_bib0046 article-title: Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy publication-title: Invest Ophthalmol Vis Sci. doi: 10.1167/iovs.08-2521 contributor: fullname: Chen – volume: 73 start-page: 13 year: 1986 ident: 10.1016/j.ajo.2024.06.005_bib0034 article-title: Longitudinal data analysis using generalized linear models publication-title: Biometrika doi: 10.1093/biomet/73.1.13 contributor: fullname: Liang – volume: 2 start-page: 972 issue: 9 year: 2018 ident: 10.1016/j.ajo.2024.06.005_bib0003 article-title: OCT angiography in young children with a history of retinopathy of prematurity publication-title: Ophthalmol Retina doi: 10.1016/j.oret.2018.02.004 contributor: fullname: Bowl – volume: 167 start-page: 52 issue: 1 year: 2015 ident: 10.1016/j.ajo.2024.06.005_bib0028 article-title: Safety of early high-dose recombinant erythropoietin for neuroprotection in very preterm infants publication-title: J Pediatr doi: 10.1016/j.jpeds.2015.02.052 contributor: fullname: Fauchere – volume: 37 start-page: 203 issue: 3 year: 2022 ident: 10.1016/j.ajo.2024.06.005_bib0036 article-title: Rewriting results sections in the language of evidence publication-title: Trends Ecol Evol doi: 10.1016/j.tree.2021.10.009 contributor: fullname: Muff – volume: 315 start-page: 2079 issue: 19 year: 2016 ident: 10.1016/j.ajo.2024.06.005_bib0020 article-title: Effect of early prophylactic high-dose recombinant human erythropoietin in very preterm infants on neurodevelopmental outcome at 2 years: a randomized clinical trial publication-title: JAMA doi: 10.1001/jama.2016.5504 contributor: fullname: Natalucci – volume: 37 start-page: 2289 issue: 12 year: 2017 ident: 10.1016/j.ajo.2024.06.005_bib0009 article-title: Optical coherence tomography angiography of the fovea in children born preterm publication-title: Retina doi: 10.1097/IAE.0000000000001471 contributor: fullname: Falavarjani – volume: 81 start-page: 153 issue: 2 year: 1992 ident: 10.1016/j.ajo.2024.06.005_bib0012 article-title: Cellular sites of extrarenal and renal erythropoietin production in anaemic rats publication-title: Br J Haematol doi: 10.1111/j.1365-2141.1992.tb08200.x contributor: fullname: Schuster – volume: 2 issue: 2 year: 2020 ident: 10.1016/j.ajo.2024.06.005_bib0026 article-title: Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants publication-title: Cochrane Database Syst Rev contributor: fullname: Aher – volume: 54 start-page: 695 issue: 7 year: 2017 ident: 10.1016/j.ajo.2024.06.005_bib0033 article-title: Optical coherence tomography angiography analysis of retinal vascular plexuses and choriocapillaris in patients with type 1 diabetes without diabetic retinopathy publication-title: Acta Diabetol doi: 10.1007/s00592-017-0996-8 contributor: fullname: Carnevali – volume: 259 start-page: 2131 issue: 8 year: 2021 ident: 10.1016/j.ajo.2024.06.005_bib0042 article-title: Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-021-05090-7 contributor: fullname: Vinekar – volume: 118 start-page: 1653 issue: 8 year: 2011 ident: 10.1016/j.ajo.2024.06.005_bib0032 article-title: Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity? publication-title: Ophthalmology doi: 10.1016/j.ophtha.2011.01.028 contributor: fullname: Thomas – volume: 219 start-page: 177 year: 2020 ident: 10.1016/j.ajo.2024.06.005_bib0010 article-title: Effect of prematurity on foveal development in early school-age children publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2020.06.001 contributor: fullname: Tiryaki Demir – volume: 96 start-page: 961 issue: 7 year: 2012 ident: 10.1016/j.ajo.2024.06.005_bib0008 article-title: Foveal avascular zone and foveal pit formation after preterm birth publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2012-301612 contributor: fullname: Yanni – volume: 28 start-page: 317 issue: 2 year: 2008 ident: 10.1016/j.ajo.2024.06.005_bib0014 article-title: Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-007-9155-z contributor: fullname: Fu – volume: 54 start-page: 2020 issue: 3 year: 2013 ident: 10.1016/j.ajo.2024.06.005_bib0049 article-title: Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity publication-title: Invest Ophthalmol Vis Sci. doi: 10.1167/iovs.13-11625 contributor: fullname: McCloskey – volume: 2 issue: 2 year: 2020 ident: 10.1016/j.ajo.2024.06.005_bib0027 article-title: Early erythropoiesis-stimulating agents in preterm or low birth weight infants publication-title: Cochrane Database Syst Rev contributor: fullname: Ohlsson – volume: 57 start-page: OCT235 issue: 9 year: 2016 ident: 10.1016/j.ajo.2024.06.005_bib0005 article-title: OCT-based macular structure-function correlation in dependence on birth weight and gestational age-the giessen long-term ROP study publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.15-18843 contributor: fullname: Bowl – volume: 376 start-page: 617 issue: 7 year: 2017 ident: 10.1016/j.ajo.2024.06.005_bib0002 article-title: Survival and neurodevelopmental outcomes among periviable infants publication-title: N Engl J Med doi: 10.1056/NEJMoa1605566 contributor: fullname: Younge – volume: 12 start-page: 233 issue: 3 year: 2008 ident: 10.1016/j.ajo.2024.06.005_bib0017 article-title: Human recombinant erythropoietin and the incidence of retinopathy of prematurity: a multiple regression model publication-title: J AAPOS doi: 10.1016/j.jaapos.2007.08.009 contributor: fullname: Suk – volume: 118 start-page: 2315 issue: 12 year: 2011 ident: 10.1016/j.ajo.2024.06.005_bib0006 article-title: Dynamics of human foveal development after premature birth publication-title: Ophthalmology doi: 10.1016/j.ophtha.2011.05.028 contributor: fullname: Maldonado – volume: 138 start-page: 388 issue: Pt 2 year: 2015 ident: 10.1016/j.ajo.2024.06.005_bib0019 article-title: Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants publication-title: Brain doi: 10.1093/brain/awu363 contributor: fullname: O'Gorman – volume: 12 start-page: 221 issue: 3 year: 2008 ident: 10.1016/j.ajo.2024.06.005_bib0045 article-title: A double-edged sword: erythropoietin eyed in retinopathy of prematurity publication-title: J AAPOS doi: 10.1016/j.jaapos.2008.02.001 contributor: fullname: Chen – volume: 46 start-page: 1032 issue: 8 year: 2009 ident: 10.1016/j.ajo.2024.06.005_bib0022 article-title: Erythropoietin protects retinal pigment epithelial cells from oxidative damage publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2008.11.027 contributor: fullname: Wang – volume: 67 start-page: 657 issue: 5 year: 2010 ident: 10.1016/j.ajo.2024.06.005_bib0018 article-title: Erythropoietin improves neurodevelopmental outcome of extremely preterm infants publication-title: Ann Neurol doi: 10.1002/ana.21977 contributor: fullname: Neubauer – volume: 39 start-page: 111 issue: 1 year: 2019 ident: 10.1016/j.ajo.2024.06.005_bib0044 article-title: Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity publication-title: Retina doi: 10.1097/IAE.0000000000001937 contributor: fullname: Nonobe – volume: 75 start-page: 800 issue: 4 year: 1988 ident: 10.1016/j.ajo.2024.06.005_bib0035 article-title: A sharper bonferroni procedure for multiple tests of significance publication-title: Biometrika doi: 10.1093/biomet/75.4.800 contributor: fullname: Hochberg – volume: 42 start-page: 1716 issue: 9 year: 2022 ident: 10.1016/j.ajo.2024.06.005_bib0038 article-title: Retinal thickness and foveal hypoplasia in adults born preterm with and without retinopathy of prematurity: the Gutenberg Prematurity Eye Study publication-title: Retina doi: 10.1097/IAE.0000000000003501 contributor: fullname: Fiess – volume: 198 start-page: 971 issue: 6 year: 2003 ident: 10.1016/j.ajo.2024.06.005_bib0016 article-title: Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis publication-title: J Exp Med doi: 10.1084/jem.20021067 contributor: fullname: Villa – volume: 39 start-page: 2233 issue: 11 year: 2019 ident: 10.1016/j.ajo.2024.06.005_bib0011 article-title: Visual function and optical coherence tomography angiography features in children born preterm publication-title: Retina doi: 10.1097/IAE.0000000000002301 contributor: fullname: Balasubramanian |
SSID | ssj0006747 |
Score | 2.5053055 |
Snippet | •Macular vessel density parameters are lower in children who have received EPO compared to placebo.•OCT and OCTA parameters differ between preterm- and... To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 264 |
Title | The Effect of Perinatal High‐Dose Erythropoietin on Retinal Structural and Vascular Characteristics in Children Born Preterm |
URI | https://dx.doi.org/10.1016/j.ajo.2024.06.005 https://www.ncbi.nlm.nih.gov/pubmed/38880371 https://www.proquest.com/docview/3069172063/abstract/ |
Volume | 266 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB50BfEivl1fRPAkVLdt2nSP66qsiiK-8BaSJoH10MqqBy-LP8Hf6C9xpk0FQT14a9OGhkwy803nmwnAjhFc6VA7lEAiAp5HaZCluQkst5lRsdCmqlNwfpEObvnpfXI_Af0mF4ZolV731zq90ta-Zd_P5v7jcEg5vh20VV1OLEhCBZMwheaI8xZM9U7OBhdfCjkVXDQomDo0wc2K5qUeKAUw4lUVTzrE7mfz9Bv8rMzQ8RzMevzIevUQ52HCFgswfe4j5IswRrmzuiQxKx27pOw--kPDiNDx8fZ-WD7h89FrfTzCkBKeWVmwK7rAt66rcrJUioOpwrA7z1Nl_e91nRn26vs0cHZQjgp2Oap4NUtwe3x00x8E_oyFII9E9hxoF-ciMyJKFCKZHOFMrpOO4q4bGYqxdUw3TLAxy2Nnhc2s1ibVNoytU1oJFy9DqygLuwrMuoRHLiGMYrjOlMLtjc6YyW1qOrpr2rDbTK18rEtpyIZj9iBRDpLkICueXdIG3ky-_LYeJKr6v7ptN4KSuE8o-KEKW748SXSN0DONEJG1YaWW4Nco4gy1WCzCtf99dB1m6K6m-G1ACyVlNxGqPOstmNwbh1t-QX4C-N_qKg |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB58gHoR367PCJ6E6m6bNt2jrsr6WBFfeAtJk8B6aGXVgxfxJ_gb_SXOpK0iqAdvJQ9a8iWTL51vJgCbRnClW9ohArEIeBYmQZpkJrDcpkZFQhufp6B3lnSv-fFtfDsEnToWhmSVle0vbbq31lXJTjWaO_f9PsX4NnGvanNSQRIrGIZRYgOk69p--dJ5JIKLmgNT89q16UVe6o4CAEPuc3jSFXY_b06_kU-_CR1OwWTFHtlu-YHTMGTzGRjrVf7xWXhB1FmZkJgVjp1TbB_9n2Ek53h_fdsvHrB-8FxejtCncGdW5OyCHrDVpU8mS4k4mMoNu6lUqqzzPaszw16dKgic7RWDnJ0PvKpmDq4PD6463aC6YSHIQpE-BtpFmUiNCGOFPCZDMpPpuKm4a4eGPGxN027FWJhmkbPCplZrk2jbiqxTWgkXzcNIXuR2EZh1MQ9dTAzFcJ0qhYsbj2Ims4lp6rZpwFY9tPK-TKQha4XZnUQcJOEgvcoubgCvB19-mw0SDf1f3TZqoCSuEnJ9qNwWTw8SD0Z4Lg2RjzVgoUTw8yuiFG1YJFpL_3vpOox3r3qn8vTo7GQZJqimFPutwAiiZleRtDzqNT8pPwAPf-r_ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Effect+of+Perinatal+High-Dose+Erythropoietin+on+Retinal+Structural+and+Vascular+Characteristics+in+Children+Born+Preterm&rft.jtitle=American+journal+of+ophthalmology&rft.au=Jeltsch%2C+Brida+M&rft.au=Hanson%2C+James+V+M&rft.au=F%C3%BCglistaler%2C+Jonas&rft.au=Heyard%2C+Rachel&rft.date=2024-10-01&rft.issn=1879-1891&rft.eissn=1879-1891&rft.volume=266&rft.spage=264&rft_id=info:doi/10.1016%2Fj.ajo.2024.06.005&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9394&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9394&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9394&client=summon |