Deep-seated dermatophytosis caused by Trichophyton rubrum in patient with Becker muscular dystrophy
Trichophyton rubrum is a common fungal pathogen that usually causes superficial infection limited to epidermis only, so called dermatophytosis. However in immunocompromised patients, dermatophytosis can be exceptionally more invasive with extensive lesions involving deep tissues and generating somet...
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Published in | Journal de mycologie médicale Vol. 34; no. 1; p. 101456 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Masson SAS
01.03.2024
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Abstract | Trichophyton rubrum is a common fungal pathogen that usually causes superficial infection limited to epidermis only, so called dermatophytosis. However in immunocompromised patients, dermatophytosis can be exceptionally more invasive with extensive lesions involving deep tissues and generating sometimes systemic course. We report the case of a 43-year-old heart transplanted man, who presented with multiple deep-seated nodules and papules in the inguinal areas and in the buttocks. Involvement of Trichophyton rubrum was confirmed by culture, DNA sequencing and histological examination that showed granulomatous inflammatory infiltrates with the presence of hyphae in the dermis. Antifungal therapy with oral terbinafine for four weeks was successful; in spite of initial remnant atrophic scars, the lesions were completely cleared after four month evolution. Deep-seated invasive dermatophytosis is rare, but should be considered with immunocompromised conditions, especially when history of previous superficial dermatophytosis is present. |
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AbstractList | Trichophyton rubrum is a common fungal pathogen that usually causes superficial infection limited to epidermis only, so called dermatophytosis. However in immunocompromised patients, dermatophytosis can be exceptionally more invasive with extensive lesions involving deep tissues and generating sometimes systemic course. We report the case of a 43-year-old heart transplanted man, who presented with multiple deep-seated nodules and papules in the inguinal areas and in the buttocks. Involvement of Trichophyton rubrum was confirmed by culture, DNA sequencing and histological examination that showed granulomatous inflammatory infiltrates with the presence of hyphae in the dermis. Antifungal therapy with oral terbinafine for four weeks was successful; in spite of initial remnant atrophic scars, the lesions were completely cleared after four month evolution. Deep-seated invasive dermatophytosis is rare, but should be considered with immunocompromised conditions, especially when history of previous superficial dermatophytosis is present. |
ArticleNumber | 101456 |
Author | Leducq, Sophie Desoubeaux, Guillaume Mirguet, Christian Ouaaziz, Ilham Bailly, Éric Chesnay, Adélaïde Marchand, Antoine Pinieux, Gonzague de |
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Cites_doi | 10.5021/ad.2019.31.S.S32 10.1016/j.mmcr.2018.03.001 10.3109/13693780903213512 10.1186/s12879-016-1631-y 10.1111/tid.12799 10.3389/fmed.2019.00097 10.1016/j.abd.2021.05.014 10.1056/NEJMoa1208487 10.1186/s12879-019-3897-3 |
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Keywords | Trichophyton rubrum Immunosuppression Deep-seated dermatophytosis |
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SubjectTerms | Deep-seated dermatophytosis Immunosuppression Trichophyton rubrum |
Title | Deep-seated dermatophytosis caused by Trichophyton rubrum in patient with Becker muscular dystrophy |
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