ALLERDB database and integrated bioinformatic tools for assessment of allergenicity and allergic cross-reactivity

• Published in: Cellular immunology Vol. 244; no. 2; pp. 90 - 96
• Main Authors: Zhang, Zong Hong, Tan, Stephanie C.C., Koh, Judice L.Y., Falus, András, Brusic, Vladimir
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2006
• Subjects: Allergen nomenclature; Allergenicity; Allergens - genetics; Allergens - immunology; Allergic cross-reactivity; Computational Biology; Cross Reactions; Databases, Factual; FAO/WHO decision tree; Humans; Hypersensitivity - immunology; Internet; FAO/WHO decision tree; Allergen nomenclature; Allergenicity; Allergic cross-reactivity
• ISSN: 0008-8749; 1090-2163
• DOI: 10.1016/j.cellimm.2007.01.007

Databases and computational tools are increasingly important in the study of allergies, particularly in the assessment of allergenicity and allergic cross-reactivity. ALLERDB database contains sequences of allergens and information on reported cross-reactivity between allergens. It focuses on analysis of allergenicity and allergic cross-reactivity of clinically relevant protein allergens. The official IUIS allergen data were extracted from the IUIS Allergen Nomenclature Sub-Committee website, and their sequence information from the public databases, and reference publications. The analysis tools assist allergen data analysis and retrieval, and include keyword searching, BLAST, prediction of allergenicity, modification of BLAST that displays cross-reactive allergens, and graphics representation of cross-reactivity data. ALLERDB is new brand of allergen databases with a rich set of tools for sequence comparison, pattern identification, and visualization of results. It is accessible at http://research.i2r.a-star.edu.sg/Templar/DB/Allergen.