Structural basis for the inhibition of βFXIIa by garadacimab

• Published in: Structure (London) Vol. 32; no. 10; pp. 1705 - 1710.e3
• Main Authors: Drulyte, Ieva, Ghai, Rajesh, Ow, Saw Yen, Kapp, Eugene A., Quek, Adam J., Panousis, Con, Wilson, Michael J., Nash, Andrew D., Pelzing, Matthias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.10.2024
• Subjects: antigen-antibody complex; C1 esterase inhibitor; cryo-EM; epitope mapping; garadacimab; HDX-MS; hereditary angioedema; paratope; βFXIIa; hereditary angioedema; βFXIIa; antigen-antibody complex; HDX-MS; paratope; cryo-EM; garadacimab; C1 esterase inhibitor; epitope mapping

Activated FXII (FXIIa) is the principal initiator of the plasma contact system and can activate both procoagulant and proinflammatory pathways. Its activity is important in the pathophysiology of hereditary angioedema (HAE). Here, we describe a high-resolution cryoelectron microscopy (cryo-EM) struc...