Differential changes in mast cells with food reintroduction in children with eosinophilic esophagitis

• Published in: Journal of leukocyte biology Vol. 116; no. 6; p. 1412
• Main Authors: Ebanks, Andrew, Wang, Ming-Yu, Hoffmann, Natalie, Wershil, Barry K, Wechsler, Joshua B
• Format: Journal Article
• Language: English
• Published: England 27.11.2024
• Subjects: Adolescent; Child; Child, Preschool; Eosinophilic Esophagitis - immunology; Eosinophilic Esophagitis - pathology; Esophagus - immunology; Esophagus - pathology; Female; Food - adverse effects; Food Hypersensitivity - immunology; Food Hypersensitivity - pathology; Humans; Male; Mast Cells - immunology; Mast Cells - pathology; Milk; treatment; outcome measure; inflammation; allergy; eosinophils; biomarker; disease pathogenesis; mast cells; dairy

Intraepithelial mast cells (MCs) are increased in eosinophilic esophagitis (EoE) and reduced with elimination of dietary antigens. Single food reintroduction can identify triggers of eosinophilia; however, the extent to which specific foods trigger intraepithelial mastocytosis remains unknown. We hy...