Alzheimer's disease clinical variants show distinct neuroinflammatory profiles with neuropathology

• Published in: Neuropathology and applied neurobiology Vol. 50; no. 5; pp. e13009 - n/a
• Main Authors: Boon, Baayla D. C., Frigerio, Irene, Gooijer, Danae, Morrema, Tjado H. J., Bol, John, Galis ‐ de Graaf, Yvon, Heymans, Martijn, Murray, Melissa E., Lee, Sven J., Holstege, Henne, Berg, Wilma D. J., Jonkman, Laura E., Rozemuller, Annemieke J. M., Bouwman, Femke H., Hoozemans, Jeroen J. M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; amyloid; Amyloid beta-Peptides - metabolism; Anatomy; Astrocytes; Atrophy; Brain - pathology; Brain architecture; complement; Cortex (frontal); Cortex (parietal); Encephalopathy; Executive function; Female; Glial fibrillary acidic protein; Hippocampus; Humans; Lewy bodies; Lewy body disease; Male; Middle Aged; Myeloid cells; Neurodegenerative diseases; Neuroinflammatory Diseases - pathology; Neuropathology; Pathology; Tau protein; tau proteins; tau Proteins - metabolism; β-Amyloid; amyloid; myeloid cells; tau proteins; astrocytes; complement; Alzheimer's disease

Aims Although the neuroanatomical distribution of tau and amyloid‐β is well studied in Alzheimer's disease (AD) (non)‐amnestic clinical variants, that of neuroinflammation remains unexplored. We investigate the neuroanatomical distribution of activated myeloid cells, astrocytes, and complement...