Irisin alleviates chronic constriction injury-induced hyperalgesia and affective disorders in mice through NF-κB and Nrf2 signaling pathways

• Published in: IBRO neuroscience reports Vol. 17; pp. 280 - 289
• Main Authors: Xie, Xupei, Yu, Xuefeng, Zhang, Hanqin, Dai, Huidan, Huang, Yuyang, Wu, Fan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2024; Elsevier
• Subjects: Affective disorders; Chronic constriction injury; Irisin; Neurodynia; NF-κB; Nrf2; Research Paper; Irisin; NF-κB; Affective disorders; Neurodynia; Nrf2; Chronic constriction injury

This research is to explore the impacts of irisin on hyperalgesia and behavioral deficits caused by chronic constriction injury (CCI) and the underlying mechanisms. The CCI mice model was used in this study. The experimental mice were assigned into sham, sham + irisin (3 μg/kg), CCI, CCI + irisin (0...