CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood

• Published in: Arthritis research & therapy Vol. 16; no. 2; p. R97
• Main Authors: Moradi, Babak, Schnatzer, Philipp, Hagmann, Sébastien, Rosshirt, Nils, Gotterbarm, Tobias, Kretzer, Jan Philippe, Thomsen, Marc, Lorenz, Hanns-Martin, Zeifang, Felix, Tretter, Theresa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.04.2014; BioMed Central
• Subjects: Aged; Analysis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; Female; Flow Cytometry; Humans; Knee Joint - immunology; Male; Memory (Computers); Middle Aged; Osteoarthritis - blood; Osteoarthritis - immunology; Phenotype; Physiological aspects; Synovial Fluid - immunology; Synovial Membrane - immunology; T-Lymphocytes, Regulatory - immunology

CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analysis of peripheral blood (PB) and synovial fluid (SF). Because Tregs exert their anti-inf...