Viral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories

• Published in: Journal of medical virology Vol. 96; no. 10; pp. e70002 - n/a
• Main Authors: Ferré, Valentine Marie, Coppée, Romain, Gbeasor‐Komlanvi, Fifonsi A., Vacher, Sophie, Bridier‐Nahmias, Antoine, Bucau, Margot, Salou, Mounerou, Lameiras, Sonia, Couvelard, Anne, Dagnra, Anoumou Claver, Bieche, Ivan, Descamps, Diane, Ekouevi, Didier K., Ghosn, Jade, Charpentier, Charlotte
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2024
• Subjects: Adult; anal; Anal Canal - virology; APOBEC Deaminases - genetics; APOBEC3; Carcinogens; cervical; Cervical cancer; Cervix Uteri - virology; Conserved sequence; Cytidine Deaminase - genetics; E6 gene; Editing; Female; Gene sequencing; Genes; Genetic diversity; Genetic Variation; Genome, Viral - genetics; Genomes; High-Throughput Nucleotide Sequencing; Human papillomavirus; Humans; Immune response; Innate immunity; Mutation; Nucleotide sequence; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomavirus Infections - genetics; Papillomavirus Infections - virology; Risk; Sex Workers; Whole Genome Sequencing; Young Adult; whole genome sequencing; genetic diversity; cervical; APOBEC3; anal; human papillomavirus

High‐risk human papillomavirus (HPV) infections are responsible for cervical cancer. However, little is known about the differences between HPV types and risk categories regarding their genetic diversity and particularly APOBEC3‐induced mutations – which contribute to the innate immune response to H...