PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles

• Published in: Journal of functional biomaterials Vol. 15; no. 10; p. 311
• Main Authors: Santos-Silva, Thamires, Viana, Inácio Silva, Queiroz, Andrea Barros Piazzon S, de Oliveira, Fabrício Singaretti, Horvath-Pereira, Bianca de Oliveira, da Silva-Júnior, Leandro Norberto, Araujo, Michelle Silva, Canola, Paulo Alescio, Dias, Luís Gustavo Gosuen G, Soares, Marcelo Melo, Miglino, Maria Angelica
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.10.2024; MDPI
• Subjects: Adhesion; Animals; Biocompatibility; Biomaterials; Biomedical materials; Bone biomaterials; bone defect; Bone growth; Bone healing; Cell adhesion; Cell size; Computed tomography; computed tomography scans; Cytotoxicity; decellularization; Electron microscopes; Ethics; Extracellular matrix; Fractures; Goats; Graphene; Hydrogels; Mandible; Mechanical properties; Medical innovations; Mesenchymal stem cells; Metal plates; Neoplasms; Osteoprogenitor cells; Placenta; Polylactic acid; Progenitor cells; Regeneration; Regeneration (physiology); Scaffolds; Scanning electron microscopy; Stem cells; Surgical equipment; Thermography; Three dimensional printing; Tissue engineering; Vascularization; Brazil; United States > US; tissue engineering; bone defect; computed tomography scans; decellularization; biomaterials

Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for b...