PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles

Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for b...

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Published inJournal of functional biomaterials Vol. 15; no. 10; p. 311
Main Authors Santos-Silva, Thamires, Viana, Inácio Silva, Queiroz, Andrea Barros Piazzon S, de Oliveira, Fabrício Singaretti, Horvath-Pereira, Bianca de Oliveira, da Silva-Júnior, Leandro Norberto, Araujo, Michelle Silva, Canola, Paulo Alescio, Dias, Luís Gustavo Gosuen G, Soares, Marcelo Melo, Miglino, Maria Angelica
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.10.2024
MDPI
Subjects
Adhesion
Animals
Biocompatibility
Biomaterials
Biomedical materials
Bone biomaterials
bone defect
Bone growth
Bone healing
Cell adhesion
Cell size
Computed tomography
computed tomography scans
Cytotoxicity
decellularization
Electron microscopes
Ethics
Extracellular matrix
Fractures
Goats
Graphene
Hydrogels
Mandible
Mechanical properties
Medical innovations
Mesenchymal stem cells
Metal plates
Neoplasms
Osteoprogenitor cells
Placenta
Polylactic acid
Progenitor cells
Regeneration
Regeneration (physiology)
Scaffolds
Scanning electron microscopy
Stem cells
Surgical equipment
Thermography
Three dimensional printing
Tissue engineering
Vascularization
Brazil
United States > US
tissue engineering
bone defect
computed tomography scans
decellularization
biomaterials
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Abstract Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation. Ten canine placentas were decellularized and characterized using histological techniques. A hydrogel derived from the canine placenta extracellular matrix (cpECM) was produced to improve cell attachment to the scaffolds. In vitro cytotoxicity and cell adhesion to the cpECM hydrogel were assessed by scanning electron microscopy (SEM). The resulting biomaterials, cpECM hydrogel and PLLA/GO scaffolds, maintained their functional structure and supported cell adhesion, maintenance, and proliferation in vitro. Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. These findings demonstrate the innovative technological potential of these materials for use in surgical interventions. Future studies on PLLA/GO scaffolds will provide further insights into their effects on goat models.
AbstractList Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation. Ten canine placentas were decellularized and characterized using histological techniques. A hydrogel derived from the canine placenta extracellular matrix (cpECM) was produced to improve cell attachment to the scaffolds. In vitro cytotoxicity and cell adhesion to the cpECM hydrogel were assessed by scanning electron microscopy (SEM). The resulting biomaterials, cpECM hydrogel and PLLA/GO scaffolds, maintained their functional structure and supported cell adhesion, maintenance, and proliferation in vitro. Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. These findings demonstrate the innovative technological potential of these materials for use in surgical interventions. Future studies on PLLA/GO scaffolds will provide further insights into their effects on goat models.
Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation. Ten canine placentas were decellularized and characterized using histological techniques. A hydrogel derived from the canine placenta extracellular matrix (cpECM) was produced to improve cell attachment to the scaffolds. In vitro cytotoxicity and cell adhesion to the cpECM hydrogel were assessed by scanning electron microscopy (SEM). The resulting biomaterials, cpECM hydrogel and PLLA/GO scaffolds, maintained their functional structure and supported cell adhesion, maintenance, and proliferation in vitro. Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. These findings demonstrate the innovative technological potential of these materials for use in surgical interventions. Future studies on PLLA/GO scaffolds will provide further insights into their effects on goat models.Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation. Ten canine placentas were decellularized and characterized using histological techniques. A hydrogel derived from the canine placenta extracellular matrix (cpECM) was produced to improve cell attachment to the scaffolds. In vitro cytotoxicity and cell adhesion to the cpECM hydrogel were assessed by scanning electron microscopy (SEM). The resulting biomaterials, cpECM hydrogel and PLLA/GO scaffolds, maintained their functional structure and supported cell adhesion, maintenance, and proliferation in vitro. Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. These findings demonstrate the innovative technological potential of these materials for use in surgical interventions. Future studies on PLLA/GO scaffolds will provide further insights into their effects on goat models.
Author da Silva-Júnior, Leandro Norberto
Canola, Paulo Alescio
de Oliveira, Fabrício Singaretti
Santos-Silva, Thamires
Queiroz, Andrea Barros Piazzon S
Araujo, Michelle Silva
Horvath-Pereira, Bianca de Oliveira
Soares, Marcelo Melo
Viana, Inácio Silva
Dias, Luís Gustavo Gosuen G
Miglino, Maria Angelica
AuthorAffiliation 2 Department of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University, Jaboticabal Campus 14884-900, SP, Brazil; inacio.viana@unesp.br (I.S.V.); paulo.canola@unesp.br (P.A.C.); gustavo.gosuen@unesp.br (L.G.G.G.D.)
5 Department of Animal Anatomy, University of Marilia, Mirante, Marília 17525-902, SP, Brazil
4 Institute of Orofacial Osteogenesis Rehabilitation S/S Ltda., Vila Olímpia 04532-060, SP, Brazil; marcelomelo61@gmail.com
1 Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, SP, Brazil; thamiresssilva@usp.br (T.S.-S.); horvath@usp.br (B.d.O.H.-P.); leandronorberto@unimar.br (L.N.d.S.-J.); msa.vet@hotmail.com (M.S.A.)
3 Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, Jaboticabal Campus 14884-900, SP, Brazil; andrea.queiroz@unesp.br (A.B.P.S.Q.); fabricio.singaretti@unesp.br (F.S.d.O.)
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Keywords tissue engineering
bone defect
computed tomography scans
decellularization
biomaterials
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Snippet Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical...
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StartPage 311
SubjectTerms Adhesion
Animals
Biocompatibility
Biomaterials
Biomedical materials
Bone biomaterials
bone defect
Bone growth
Bone healing
Cell adhesion
Cell size
Computed tomography
computed tomography scans
Cytotoxicity
decellularization
Electron microscopes
Ethics
Extracellular matrix
Fractures
Goats
Graphene
Hydrogels
Mandible
Mechanical properties
Medical innovations
Mesenchymal stem cells
Metal plates
Neoplasms
Osteoprogenitor cells
Placenta
Polylactic acid
Progenitor cells
Regeneration
Regeneration (physiology)
Scaffolds
Scanning electron microscopy
Stem cells
Surgical equipment
Thermography
Three dimensional printing
Tissue engineering
Vascularization
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Title PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles
URI https://www.ncbi.nlm.nih.gov/pubmed/39452609
https://www.proquest.com/docview/3120675325
https://www.proquest.com/docview/3120600527
https://pubmed.ncbi.nlm.nih.gov/PMC11508647
https://doaj.org/article/150331d2d3f345de9cdd217d21911207
Volume 15
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