The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 5; no. 4; pp. 477 - 479
• Main Authors: Kaïm, L. El, Gautier, L., Grimaud, L., Harwood, L. M., Michaut, V.
• Format: Journal Article
• Language: English
• Published: 01.01.2003

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of sim...