The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of sim...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 5; no. 4; pp. 477 - 479
Main Authors Kaïm, L. El, Gautier, L., Grimaud, L., Harwood, L. M., Michaut, V.
Format Journal Article
LanguageEnglish
Published 01.01.2003
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Abstract The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.
AbstractList The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.
Author Gautier, L.
Harwood, L. M.
Grimaud, L.
Kaïm, L. El
Michaut, V.
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