The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions
The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of sim...
Saved in:
Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 5; no. 4; pp. 477 - 479 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2003
|
Online Access | Get full text |
Cover
Loading…
Summary: | The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with -nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/B306242B |