Evidence for direct action of testosterone on rat liver cells : in vivo and in vitro induction of unusual estrogen-binding protein

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 42; no. 2; pp. 243 - 249
• Main Authors: SMIRNOVA, O. V, VISHNYAKOVA, T. G, BOCHAROV, A. V, KOVTUN, I. V, ROZEN, V. B
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science 01.04.1992
• Subjects: Animals; Biological and medical sciences; Carrier Proteins - biosynthesis; Female; Fundamental and applied biological sciences. Psychology; Hypophysectomy; Liver - cytology; Liver - metabolism; Liver - physiology; Liver Regeneration; Liver. Bile. Biliary tracts; Male; Orchiectomy; Ovariectomy; Rats; Receptors, Estrogen; Testosterone - physiology; Vertebrates: digestive system; Androgen; Rat; Liver; STH; Rodentia; Estrogen; Binding protein; Testosterone; Vertebrata; Mammalia; Adenohypophyseal hormone; Hepatocyte; Sexual dimorphism; Sex steroid hormone

We demonstrate that on the rat liver, testosterone (T) induced differentiated functions and enhanced unusual estrogen-binding protein (UEBP) content through mechanisms dependent on cell activation by androgens, the presence of growth hormone (GH) and the hormonal status of the animal. To determine w...