NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation

• Published in: Neurochemistry international Vol. 134; p. 104652
• Main Authors: Kumar, Sanjay, Vinayak, Manjula
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2020
• Subjects: Acute pain; Animals; Astrocytes - drug effects; Astrocytes - metabolism; Central Nervous System Sensitization - drug effects; ERK1/2; Formaldehyde - pharmacology; Glia; Male; Mice; ML171; NADP - drug effects; NADP - metabolism; NADPH Oxidases - drug effects; Neuroglia - drug effects; Neuroglia - metabolism; Neurons - drug effects; Neurons - metabolism; NF-kappa B - metabolism; NFκB; Nociception - drug effects; NOX1; Pain - drug therapy; Pain - metabolism; Signal Transduction - drug effects; ERK1/2; Acute pain; NFκB; Glia; ML171; NOX1

Role of NADPH oxidase1 in the development of inflammatory pain has been demonstrated by gene knockout studies. Nevertheless, pharmacological inhibition of NOX1 is a requisite approach for therapeutic utility. Recently, we have reported the anti-nociceptive effect of newly identified NOX1 specific in...