17β-oestradiol alleviates endoplasmic reticulum stress injury induced by chronic cerebral hypoperfusion through the Haemoglobin/HIF 1α signalling pathway in ovariectomized rats

• Published in: Neurochemistry international Vol. 148; p. 105119
• Main Authors: Xu, Chao, Dai, Yongxin, Bai, Jing, Ren, Bo, Xu, Jing, Gao, Fujia, Wang, Lu, Zhang, Wenli, Wang, Ruimin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2021
• Subjects: 17β-oestradiol; Animals; CA1 Region, Hippocampal - metabolism; Carotid Stenosis - complications; Carotid Stenosis - pathology; Cerebrovascular Circulation; Cerebrovascular Disorders - drug therapy; Chronic cerebral hypoperfusion; Dementia, Vascular - drug therapy; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Estradiol - pharmacology; Estradiol - therapeutic use; Female; Haemoglobin; Hemoglobins - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1α; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Ovariectomy; Oxygen - blood; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Haemoglobin; Hypoxia-inducible factor 1α; Chronic cerebral hypoperfusion; 17β-oestradiol; Endoplasmic reticulum stress

Endoplasmic reticulum stress (ERS) is known to be an essential target in protecting against ischaemic brain injury. In this study, using a vascular dementia (VaD) animal model induced by bilateral common carotid artery occlusion (BCCAO), we evaluated the effect and mechanism of 17β-oestradiol (E2) a...