Xanthium strumarium´s xanthatins induces mitotic arrest and apoptosis in CT26WT colon carcinoma cells
Colorectal cancer is one of the most common malignancies worldwide and is associated with high mortality rates. We previously reported that Xanthium strumarium L. induces mitotic arrest in proliferating cells, a process mediated by xanthatins. The aim of this work is to study if xanthatins, isolated...
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| Published in | Phytomedicine (Stuttgart) Vol. 57; pp. 236 - 244 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier GmbH
01.04.2019
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| Abstract | Colorectal cancer is one of the most common malignancies worldwide and is associated with high mortality rates. We previously reported that Xanthium strumarium L. induces mitotic arrest in proliferating cells, a process mediated by xanthatins.
The aim of this work is to study if xanthatins, isolated from X. strumarium total extract, affect the proliferative capacity of CT26WT colon cancer cells and, in consequence, if tumor growth and proliferation of (lung) metastatic sites can also be arrested in vivo.
This study consisted of both in vitro and in vivo experiments involving the CT26WT cell line and a subcutaneous mouse model of colon cancer. In vitro cell cycle progression, in vivo tumoral growth and anti-metastatic activity were analyzed to investigate whether xanthatins of X. strumarium induce mitotic arrest in proliferating colorectal carcinoma.
Our in vitro results show that X. strumarium, mediated by xanthatins, induces G2/M arrest and impair anaphase entrance. This leads to a significant induction of apoptotic and necrotic in CT26WT cells, demonstrating their significant anti-proliferative activity through interfering with the mitotic apparatus. Furthermore, our in vivoresults reveal that X. strumarium inhibits both tumor growth and metastasis progression.
X. strumarium antitumor activities are mainly mediated by xanthatins through inhibition of tumor growth and metastasis, inducing mitotic arrest and apoptosis in colon carcinoma cells. These findings further confirm the therapeutic potential of X. strumarium in colorectal cancer.
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| AbstractList | Colorectal cancer is one of the most common malignancies worldwide and is associated with high mortality rates. We previously reported that Xanthium strumarium L. induces mitotic arrest in proliferating cells, a process mediated by xanthatins.
The aim of this work is to study if xanthatins, isolated from X. strumarium total extract, affect the proliferative capacity of CT26WT colon cancer cells and, in consequence, if tumor growth and proliferation of (lung) metastatic sites can also be arrested in vivo.
This study consisted of both in vitro and in vivo experiments involving the CT26WT cell line and a subcutaneous mouse model of colon cancer. In vitro cell cycle progression, in vivo tumoral growth and anti-metastatic activity were analyzed to investigate whether xanthatins of X. strumarium induce mitotic arrest in proliferating colorectal carcinoma.
Our in vitro results show that X. strumarium, mediated by xanthatins, induces G2/M arrest and impair anaphase entrance. This leads to a significant induction of apoptotic and necrotic in CT26WT cells, demonstrating their significant anti-proliferative activity through interfering with the mitotic apparatus. Furthermore, our in vivoresults reveal that X. strumarium inhibits both tumor growth and metastasis progression.
X. strumarium antitumor activities are mainly mediated by xanthatins through inhibition of tumor growth and metastasis, inducing mitotic arrest and apoptosis in colon carcinoma cells. These findings further confirm the therapeutic potential of X. strumarium in colorectal cancer.
[Display omitted] Colorectal cancer is one of the most common malignancies worldwide and is associated with high mortality rates. We previously reported that Xanthium strumarium L. induces mitotic arrest in proliferating cells, a process mediated by xanthatins. The aim of this work is to study if xanthatins, isolated from X. strumarium total extract, affect the proliferative capacity of CT26WT colon cancer cells and, in consequence, if tumor growth and proliferation of (lung) metastatic sites can also be arrested in vivo. This study consisted of both in vitro and in vivo experiments involving the CT26WT cell line and a subcutaneous mouse model of colon cancer. In vitro cell cycle progression, in vivo tumoral growth and anti-metastatic activity were analyzed to investigate whether xanthatins of X. strumarium induce mitotic arrest in proliferating colorectal carcinoma. Our in vitro results show that X. strumarium, mediated by xanthatins, induces G /M arrest and impair anaphase entrance. This leads to a significant induction of apoptotic and necrotic in CT26WT cells, demonstrating their significant anti-proliferative activity through interfering with the mitotic apparatus. Furthermore, our in vivoresults reveal that X. strumarium inhibits both tumor growth and metastasis progression. X. strumarium antitumor activities are mainly mediated by xanthatins through inhibition of tumor growth and metastasis, inducing mitotic arrest and apoptosis in colon carcinoma cells. These findings further confirm the therapeutic potential of X. strumarium in colorectal cancer. |
| Author | González, Maria L. Sánchez-Lamar, Ángel Pérez, Carlos Lopes, Miriam Teresa Paz Piloto-Ferrer, Janet Francisco, Marbelis Rodeiro, Idania Aparicio, Guillermo Merino, Nelsón |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30797985$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1038_s41598_020_66847_4 crossref_primary_10_1167_iovs_62_15_11 crossref_primary_10_32604_phyton_2022_019219 crossref_primary_10_4103_wjtcm_wjtcm_49_20 crossref_primary_10_1016_j_jep_2020_113479 crossref_primary_10_1002_ddr_21850 crossref_primary_10_1007_s00894_022_05428_w crossref_primary_10_1080_17460441_2023_2147920 crossref_primary_10_3390_plants12091840 crossref_primary_10_1016_j_sajb_2020_08_006 crossref_primary_10_1155_2019_6073019 |
| Cites_doi | 10.1021/jf4034688 10.1055/s-2003-38879 10.1371/journal.pone.0081945 10.1038/nri1809 10.1016/j.vaccine.2012.01.006 10.1002/ptr.4888 10.1016/j.bcp.2016.06.009 10.18632/oncotarget.2484 10.3748/wjg.v22.i30.6876 10.1080/10412905.2010.9700363 10.1016/j.sjbs.2016.07.003 10.1016/j.drudis.2012.01.013 10.1186/1471-2164-15-190 10.1016/j.cub.2015.08.051 10.1038/nprot.2006.339 10.1016/j.drup.2007.01.003 10.18632/oncotarget.6553 10.1016/0022-1759(83)90303-4 10.1002/mc.22185 10.1016/j.ejmech.2014.11.060 10.3322/caac.21208 10.3322/caac.21492 10.3322/caac.21387 10.1016/j.phrs.2009.01.017 10.3390/molecules17043736 10.1006/bbrc.2002.6754 10.1515/znc-2009-5-607 10.1016/j.phymed.2013.03.006 10.1016/S1535-6108(03)00110-7 10.1177/1758834015614530 10.1016/j.ijpharm.2009.08.041 10.1016/j.jep.2016.11.006 10.1002/ptr.6087 10.2131/jts.38.547 10.1039/c0np00011f 10.1002/ptr.3651 10.1055/s-0031-1298481 10.1139/Y07-104 |
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| Keywords | WEXs Anti-proliferative CEXs Colon cancer Anti-mitotic Xanthatins SAC Anti-metastatic Chk1 Chk2 XF Xanthium strumarium |
| Language | English |
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| References | Yu, Yu, Pei, Li, Tu (bib0038) 2015; 8 Vasas, Hohmann (bib0037) 2011; 28 Sharma, Bajpai, Shukla (bib0029) 2013 Castle, Loewer, Boegel, de Graaf, Bender (bib1002) 2014; 15 Siegel (bib0033) 2006; 6 Kim, Kim, Park, Choi, Lee (bib0010) 2003; 69 Na, Lim, Jeong, Lee, Lim (bib0016) 2010; 383 Piloto-Ferrer, Zampini, Cuello, Francisco, Romero (bib0021) 2016; 11 Sánchez-Lamar, Piloto-Ferrer, Fiore, Stano, Cozzi (bib0025) 2016; 194 Siegel, Ma, Zou, Jemal (bib0031) 2014; 64 Salehi, Zucca, Sharifi‐Rad, Pezzani, Rajabi (bib0024) 2018; 32 Nobili, Lippi, Witort, Donnini, Bausi (bib0020) 2009; 59 Schnyder, Schnyder-Candrian, Panski, Bommel, Heim (bib0028) 2002; 292 Nibret, Youns, Krauth-Siegel, Wink (bib0019) 2011; 25 Tao, Sheng, Zhang, Li, Wei (bib0036) 2016; 115 Bequet-Romero, Morera, Ayala-Avila, Ancizar, Soria (bib0003) 2012; 30 Bartek, Lukas (bib0002) 2003; 3 Shin, Kim, Yoon, Choi, Koh (bib0030) 2013; 61 Takeda, Nishimura, Koyachi, Matsumoto, Yoshida (bib0034) 2013; 38 Nagaraju, Alese, Landry, Diaz, El-Rayes (bib0017) 2014; 5 Hu, Li, Gao, Cho (bib0008) 2016; 22 Hammond, Swaika, Mody (bib0007) 2016; 8 Scherer, Wagner, Meireles, Godoy, Duarte (bib0027) 2010; 22 Musacchio (bib0015) 2015; 25 Maddika, Ande, Panigrahi, Paranjothy, Weglarczyk (bib0013) 2007; 10 Mosmann (bib0014) 1983; 65 Tao, Fan, Liu, Li, Zhang (bib0035) 2013; 8 Janecka, Wyrebska, Gach, Fichna, Janecki (bib0009) 2012; 17 Sankpal, Nagaraju, Gottipolu, Hurtado, Jordan (bib0026) 2016; 7 Bray, Ferlay, Soerjomataram, Siegel, Torre (bib0004) 2018; 68 Fidler (bib0005) 1978; 15 Franken, Rodermond, Stap, Haveman, van Bree (bib0006) 2006; 1 Zhang, Tao, Ruan, Li, Wu (bib0040) 2012; 78 Romero, Zanuy, Rosell, Cascante, Piulats (bib0023) 2015; 90 Zhang, Ruan, Yan, Li, Wu (bib0039) 2012; 17 Siegel, Miller, Jemal (bib0032) 2017; 67 Li, Wu, Zhang, Yan, Yin (bib0012) 2013; 20 Al-Mekhlafi, Abutaha, Mashaly, Nasr, Ibrahim (bib0001) 2017; 24 Kim, Jung, Byun, Son, Oh (bib1003) 2013; 27 Nagaraju, Long, Park, Landry, Taliaferro‐Smith (bib0018) 2015; 54 Kovacs, Vasas, Forgo, Rethy, Zupko (bib0011) 2009; 64 Ramirez-Erosa, Huang, Hickie, Sutherland, Barl (bib0022) 2007; 85 Shin (10.1016/j.phymed.2018.12.019_bib0030) 2013; 61 Siegel (10.1016/j.phymed.2018.12.019_bib0032) 2017; 67 Scherer (10.1016/j.phymed.2018.12.019_bib0027) 2010; 22 Siegel (10.1016/j.phymed.2018.12.019_bib0033) 2006; 6 Nagaraju (10.1016/j.phymed.2018.12.019_bib0018) 2015; 54 Yu (10.1016/j.phymed.2018.12.019_bib0038) 2015; 8 Franken (10.1016/j.phymed.2018.12.019_bib0006) 2006; 1 Na (10.1016/j.phymed.2018.12.019_bib0016) 2010; 383 Siegel (10.1016/j.phymed.2018.12.019_bib0031) 2014; 64 Maddika (10.1016/j.phymed.2018.12.019_bib0013) 2007; 10 Tao (10.1016/j.phymed.2018.12.019_bib0035) 2013; 8 Zhang (10.1016/j.phymed.2018.12.019_bib0039) 2012; 17 Li (10.1016/j.phymed.2018.12.019_bib0012) 2013; 20 Takeda (10.1016/j.phymed.2018.12.019_bib0034) 2013; 38 Musacchio (10.1016/j.phymed.2018.12.019_bib0015) 2015; 25 Piloto-Ferrer (10.1016/j.phymed.2018.12.019_bib0021) 2016; 11 Sharma (10.1016/j.phymed.2018.12.019_bib0029) 2013 Nagaraju (10.1016/j.phymed.2018.12.019_bib0017) 2014; 5 Sankpal (10.1016/j.phymed.2018.12.019_bib0026) 2016; 7 Kim (10.1016/j.phymed.2018.12.019_bib1003) 2013; 27 Hammond (10.1016/j.phymed.2018.12.019_bib0007) 2016; 8 Kovacs (10.1016/j.phymed.2018.12.019_bib0011) 2009; 64 Kim (10.1016/j.phymed.2018.12.019_bib0010) 2003; 69 Vasas (10.1016/j.phymed.2018.12.019_bib0037) 2011; 28 Salehi (10.1016/j.phymed.2018.12.019_bib0024) 2018; 32 Nibret (10.1016/j.phymed.2018.12.019_bib0019) 2011; 25 Romero (10.1016/j.phymed.2018.12.019_bib0023) 2015; 90 Hu (10.1016/j.phymed.2018.12.019_bib0008) 2016; 22 Bequet-Romero (10.1016/j.phymed.2018.12.019_bib0003) 2012; 30 Bray (10.1016/j.phymed.2018.12.019_bib0004) 2018; 68 Janecka (10.1016/j.phymed.2018.12.019_bib0009) 2012; 17 Ramirez-Erosa (10.1016/j.phymed.2018.12.019_bib0022) 2007; 85 Tao (10.1016/j.phymed.2018.12.019_bib0036) 2016; 115 Zhang (10.1016/j.phymed.2018.12.019_bib0040) 2012; 78 Nobili (10.1016/j.phymed.2018.12.019_bib0020) 2009; 59 Mosmann (10.1016/j.phymed.2018.12.019_bib0014) 1983; 65 Sánchez-Lamar (10.1016/j.phymed.2018.12.019_bib0025) 2016; 194 Schnyder (10.1016/j.phymed.2018.12.019_bib0028) 2002; 292 Al-Mekhlafi (10.1016/j.phymed.2018.12.019_bib0001) 2017; 24 Bartek (10.1016/j.phymed.2018.12.019_bib0002) 2003; 3 Castle (10.1016/j.phymed.2018.12.019_bib1002) 2014; 15 Fidler (10.1016/j.phymed.2018.12.019_bib0005) 1978; 15 |
| References_xml | – start-page: 3515 year: 2013 end-page: 3550 ident: bib0029 article-title: Sesquiterpenes and cytotoxicity publication-title: Natural Products contributor: fullname: Shukla – volume: 3 start-page: 421 year: 2003 end-page: 429 ident: bib0002 article-title: Chk1 and Chk2 kinases in checkpoint control and cancer publication-title: Cancer Cell contributor: fullname: Lukas – volume: 22 start-page: 6876 year: 2016 ident: bib0008 article-title: Mechanisms of drug resistance in colon cancer and its therapeutic strategies publication-title: World J. Gastroenterol. contributor: fullname: Cho – volume: 17 start-page: 3736 year: 2012 end-page: 3750 ident: bib0039 article-title: Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-kappaB pathway in A549 non-small-cell lung cancer cells publication-title: Molecules contributor: fullname: Wu – volume: 6 start-page: 308 year: 2006 ident: bib0033 article-title: Caspases at the crossroads of immune-cell life and death publication-title: Nat. Rev. Immunol. contributor: fullname: Siegel – volume: 68 start-page: 394 year: 2018 end-page: 424 ident: bib0004 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. contributor: fullname: Torre – volume: 15 start-page: 190 year: 2014 ident: bib1002 article-title: Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma publication-title: BMC genomics contributor: fullname: Bender – volume: 15 start-page: 399 year: 1978 end-page: 439 ident: bib0005 article-title: General considerations for studies of experimental cancer metastasis publication-title: Methods Cancer Res. contributor: fullname: Fidler – volume: 61 start-page: 12588 year: 2013 end-page: 12597 ident: bib0030 article-title: Novel antimitotic activity of 2-hydroxy-4-methoxy-2′, 3′-benzochalcone (HymnPro) through the inhibition of tubulin polymerization publication-title: J. Agric. Food Chem. contributor: fullname: Koh – volume: 25 start-page: 1883 year: 2011 end-page: 1890 ident: bib0019 article-title: Biological activities of xanthatin from publication-title: Phytother. Res. contributor: fullname: Wink – volume: 11 start-page: 371 year: 2016 end-page: 376 ident: bib0021 article-title: Cytotoxic compounds from aerial organs of publication-title: Nat. Prod. Commun. contributor: fullname: Romero – volume: 292 start-page: 841 year: 2002 end-page: 847 ident: bib0028 article-title: Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Heim – volume: 25 start-page: R1002 year: 2015 end-page: R1018 ident: bib0015 article-title: The molecular biology of spindle assembly checkpoint signaling dynamics publication-title: Curr. Biol. contributor: fullname: Musacchio – volume: 22 start-page: 424 year: 2010 end-page: 429 ident: bib0027 article-title: Biological activity and chemical composition of hydrodistilled and supercritical extracts of publication-title: J. Essent. Oil Res. contributor: fullname: Duarte – volume: 78 start-page: 890 year: 2012 end-page: 895 ident: bib0040 article-title: Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells publication-title: Planta Med. contributor: fullname: Wu – volume: 5 start-page: 9980 year: 2014 ident: bib0017 article-title: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy publication-title: Oncotarget contributor: fullname: El-Rayes – volume: 8 start-page: e81945 year: 2013 ident: bib0035 article-title: Concerted suppression of STAT3 and GSK3beta is involved in growth inhibition of non-small cell lung cancer by Xanthatin publication-title: PLoS One contributor: fullname: Zhang – volume: 67 start-page: 7 year: 2017 end-page: 30 ident: bib0032 article-title: Cancer statistics, 2017 publication-title: CA Cancer J. Clin. contributor: fullname: Jemal – volume: 38 start-page: 547 year: 2013 end-page: 557 ident: bib0034 article-title: (-) Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells publication-title: J. Toxicol. Sci. contributor: fullname: Yoshida – volume: 64 start-page: 9 year: 2014 end-page: 29 ident: bib0031 article-title: Cancer statistics, 2014 publication-title: CA Cancer J. Clin. contributor: fullname: Jemal – volume: 115 start-page: 18 year: 2016 end-page: 27 ident: bib0036 article-title: Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3beta and beta-catenin publication-title: Biochem. Pharmacol. contributor: fullname: Wei – volume: 54 start-page: 1147 year: 2015 end-page: 1158 ident: bib0018 article-title: Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer publication-title: Mol. Carcinog. contributor: fullname: Taliaferro‐Smith – volume: 27 start-page: 1481 year: 2013 end-page: 1488 ident: bib1003 article-title: Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin publication-title: Phytother Res contributor: fullname: Oh – volume: 69 start-page: 375 year: 2003 end-page: 377 ident: bib0010 article-title: Two cytotoxic sesquiterpene lactones from the leaves of publication-title: Planta Med. contributor: fullname: Lee – volume: 30 start-page: 1790 year: 2012 end-page: 1799 ident: bib0003 article-title: CIGB-247: a VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors publication-title: Vaccine contributor: fullname: Soria – volume: 64 start-page: 343 year: 2009 end-page: 349 ident: bib0011 article-title: Xanthanolides with antitumour activity from publication-title: Z. Naturforsch. C contributor: fullname: Zupko – volume: 1 start-page: 2315 year: 2006 end-page: 2319 ident: bib0006 article-title: Clonogenic assay of cells in vitro publication-title: Nat. Protoc. contributor: fullname: van Bree – volume: 32 start-page: 1 year: 2018 end-page: 25 ident: bib0024 article-title: Phytotherapeutics in cancer invasion and metastasis publication-title: Phytother. Res. contributor: fullname: Rajabi – volume: 7 start-page: 3186 year: 2016 ident: bib0026 article-title: Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species publication-title: Oncotarget contributor: fullname: Jordan – volume: 28 start-page: 824 year: 2011 end-page: 842 ident: bib0037 article-title: Xanthane sesquiterpenoids: structure, synthesis and biological activity publication-title: Nat. Prod. Rep. contributor: fullname: Hohmann – volume: 85 start-page: 1160 year: 2007 end-page: 1172 ident: bib0022 article-title: Xanthatin and xanthinosin from the burs of publication-title: Can. J. Physiol. Pharmacol. contributor: fullname: Barl – volume: 8 start-page: 57 year: 2016 end-page: 84 ident: bib0007 article-title: Pharmacologic resistance in colorectal cancer: a review publication-title: Ther. Adv. Med. Oncol. contributor: fullname: Mody – volume: 59 start-page: 365 year: 2009 end-page: 378 ident: bib0020 article-title: Natural compounds for cancer treatment and prevention publication-title: Pharmacol. Res. contributor: fullname: Bausi – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: bib0014 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods contributor: fullname: Mosmann – volume: 20 start-page: 865 year: 2013 end-page: 873 ident: bib0012 article-title: Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo publication-title: Phytomedicine contributor: fullname: Yin – volume: 8 start-page: 10355 year: 2015 end-page: 10364 ident: bib0038 article-title: Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells publication-title: Int. J. Clin. Exp. Pathol. contributor: fullname: Tu – volume: 90 start-page: 491 year: 2015 end-page: 496 ident: bib0023 article-title: Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties publication-title: Eur. J. Med. Chem. contributor: fullname: Piulats – volume: 17 start-page: 561 year: 2012 end-page: 572 ident: bib0009 article-title: Natural and synthetic alpha-methylenelactones and alpha-methylenelactams with anticancer potential publication-title: Drug Discov. Today contributor: fullname: Janecki – volume: 24 start-page: 817 year: 2017 end-page: 821 ident: bib0001 article-title: Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and publication-title: Saudi J. Biol. Sci. contributor: fullname: Ibrahim – volume: 383 start-page: 192 year: 2010 end-page: 200 ident: bib0016 article-title: Combination antitumor effects of micelle-loaded anticancer drugs in a CT-26 murine colorectal carcinoma model publication-title: Int. J. Pharm. contributor: fullname: Lim – volume: 194 start-page: 781 year: 2016 end-page: 788 ident: bib0025 article-title: extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin publication-title: J. Ethnopharmacol. contributor: fullname: Cozzi – volume: 10 start-page: 13 year: 2007 end-page: 29 ident: bib0013 article-title: Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy publication-title: Drug Resist. Updat. contributor: fullname: Weglarczyk – volume: 61 start-page: 12588 issue: 51 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib0030 article-title: Novel antimitotic activity of 2-hydroxy-4-methoxy-2′, 3′-benzochalcone (HymnPro) through the inhibition of tubulin polymerization publication-title: J. Agric. Food Chem. doi: 10.1021/jf4034688 contributor: fullname: Shin – volume: 69 start-page: 375 issue: 4 year: 2003 ident: 10.1016/j.phymed.2018.12.019_bib0010 article-title: Two cytotoxic sesquiterpene lactones from the leaves of Xanthium strumarium and their in vitro inhibitory activity on farnesyltransferase publication-title: Planta Med. doi: 10.1055/s-2003-38879 contributor: fullname: Kim – volume: 8 start-page: e81945 issue: 11 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib0035 article-title: Concerted suppression of STAT3 and GSK3beta is involved in growth inhibition of non-small cell lung cancer by Xanthatin publication-title: PLoS One doi: 10.1371/journal.pone.0081945 contributor: fullname: Tao – volume: 6 start-page: 308 issue: 4 year: 2006 ident: 10.1016/j.phymed.2018.12.019_bib0033 article-title: Caspases at the crossroads of immune-cell life and death publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1809 contributor: fullname: Siegel – volume: 30 start-page: 1790 issue: 10 year: 2012 ident: 10.1016/j.phymed.2018.12.019_bib0003 article-title: CIGB-247: a VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors publication-title: Vaccine doi: 10.1016/j.vaccine.2012.01.006 contributor: fullname: Bequet-Romero – volume: 27 start-page: 1481 issue: 10 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib1003 article-title: Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin publication-title: Phytother Res doi: 10.1002/ptr.4888 contributor: fullname: Kim – volume: 115 start-page: 18 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0036 article-title: Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3beta and beta-catenin publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2016.06.009 contributor: fullname: Tao – volume: 5 start-page: 9980 issue: 20 year: 2014 ident: 10.1016/j.phymed.2018.12.019_bib0017 article-title: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy publication-title: Oncotarget doi: 10.18632/oncotarget.2484 contributor: fullname: Nagaraju – volume: 22 start-page: 6876 issue: 30 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0008 article-title: Mechanisms of drug resistance in colon cancer and its therapeutic strategies publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v22.i30.6876 contributor: fullname: Hu – volume: 22 start-page: 424 issue: 5 year: 2010 ident: 10.1016/j.phymed.2018.12.019_bib0027 article-title: Biological activity and chemical composition of hydrodistilled and supercritical extracts of Xanthium strumarium L. leaves publication-title: J. Essent. Oil Res. doi: 10.1080/10412905.2010.9700363 contributor: fullname: Scherer – start-page: 3515 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib0029 article-title: Sesquiterpenes and cytotoxicity contributor: fullname: Sharma – volume: 24 start-page: 817 issue: 4 year: 2017 ident: 10.1016/j.phymed.2018.12.019_bib0001 article-title: Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera: Culicidae) publication-title: Saudi J. Biol. Sci. doi: 10.1016/j.sjbs.2016.07.003 contributor: fullname: Al-Mekhlafi – volume: 17 start-page: 561 issue: 11-12 year: 2012 ident: 10.1016/j.phymed.2018.12.019_bib0009 article-title: Natural and synthetic alpha-methylenelactones and alpha-methylenelactams with anticancer potential publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2012.01.013 contributor: fullname: Janecka – volume: 15 start-page: 190 issue: 1 year: 2014 ident: 10.1016/j.phymed.2018.12.019_bib1002 article-title: Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma publication-title: BMC genomics doi: 10.1186/1471-2164-15-190 contributor: fullname: Castle – volume: 25 start-page: R1002 issue: 20 year: 2015 ident: 10.1016/j.phymed.2018.12.019_bib0015 article-title: The molecular biology of spindle assembly checkpoint signaling dynamics publication-title: Curr. Biol. doi: 10.1016/j.cub.2015.08.051 contributor: fullname: Musacchio – volume: 1 start-page: 2315 issue: 5 year: 2006 ident: 10.1016/j.phymed.2018.12.019_bib0006 article-title: Clonogenic assay of cells in vitro publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.339 contributor: fullname: Franken – volume: 10 start-page: 13 issue: 1-2 year: 2007 ident: 10.1016/j.phymed.2018.12.019_bib0013 article-title: Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy publication-title: Drug Resist. Updat. doi: 10.1016/j.drup.2007.01.003 contributor: fullname: Maddika – volume: 11 start-page: 371 issue: 3 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0021 article-title: Cytotoxic compounds from aerial organs of Xanthium strumarium publication-title: Nat. Prod. Commun. contributor: fullname: Piloto-Ferrer – volume: 7 start-page: 3186 issue: 3 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0026 article-title: Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species publication-title: Oncotarget doi: 10.18632/oncotarget.6553 contributor: fullname: Sankpal – volume: 65 start-page: 55 issue: 1 year: 1983 ident: 10.1016/j.phymed.2018.12.019_bib0014 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(83)90303-4 contributor: fullname: Mosmann – volume: 15 start-page: 399 year: 1978 ident: 10.1016/j.phymed.2018.12.019_bib0005 article-title: General considerations for studies of experimental cancer metastasis publication-title: Methods Cancer Res. contributor: fullname: Fidler – volume: 54 start-page: 1147 issue: 10 year: 2015 ident: 10.1016/j.phymed.2018.12.019_bib0018 article-title: Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer publication-title: Mol. Carcinog. doi: 10.1002/mc.22185 contributor: fullname: Nagaraju – volume: 90 start-page: 491 year: 2015 ident: 10.1016/j.phymed.2018.12.019_bib0023 article-title: Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.11.060 contributor: fullname: Romero – volume: 64 start-page: 9 issue: 1 year: 2014 ident: 10.1016/j.phymed.2018.12.019_bib0031 article-title: Cancer statistics, 2014 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21208 contributor: fullname: Siegel – volume: 68 start-page: 394 issue: 6 year: 2018 ident: 10.1016/j.phymed.2018.12.019_bib0004 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21492 contributor: fullname: Bray – volume: 67 start-page: 7 issue: 1 year: 2017 ident: 10.1016/j.phymed.2018.12.019_bib0032 article-title: Cancer statistics, 2017 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21387 contributor: fullname: Siegel – volume: 59 start-page: 365 issue: 6 year: 2009 ident: 10.1016/j.phymed.2018.12.019_bib0020 article-title: Natural compounds for cancer treatment and prevention publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2009.01.017 contributor: fullname: Nobili – volume: 17 start-page: 3736 issue: 4 year: 2012 ident: 10.1016/j.phymed.2018.12.019_bib0039 article-title: Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-kappaB pathway in A549 non-small-cell lung cancer cells publication-title: Molecules doi: 10.3390/molecules17043736 contributor: fullname: Zhang – volume: 292 start-page: 841 issue: 4 year: 2002 ident: 10.1016/j.phymed.2018.12.019_bib0028 article-title: Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2002.6754 contributor: fullname: Schnyder – volume: 64 start-page: 343 issue: 5-6 year: 2009 ident: 10.1016/j.phymed.2018.12.019_bib0011 article-title: Xanthanolides with antitumour activity from Xanthium italicum publication-title: Z. Naturforsch. C doi: 10.1515/znc-2009-5-607 contributor: fullname: Kovacs – volume: 20 start-page: 865 issue: 10 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib0012 article-title: Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo publication-title: Phytomedicine doi: 10.1016/j.phymed.2013.03.006 contributor: fullname: Li – volume: 3 start-page: 421 issue: 5 year: 2003 ident: 10.1016/j.phymed.2018.12.019_bib0002 article-title: Chk1 and Chk2 kinases in checkpoint control and cancer publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00110-7 contributor: fullname: Bartek – volume: 8 start-page: 57 issue: 1 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0007 article-title: Pharmacologic resistance in colorectal cancer: a review publication-title: Ther. Adv. Med. Oncol. doi: 10.1177/1758834015614530 contributor: fullname: Hammond – volume: 383 start-page: 192 issue: 1-2 year: 2010 ident: 10.1016/j.phymed.2018.12.019_bib0016 article-title: Combination antitumor effects of micelle-loaded anticancer drugs in a CT-26 murine colorectal carcinoma model publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2009.08.041 contributor: fullname: Na – volume: 194 start-page: 781 year: 2016 ident: 10.1016/j.phymed.2018.12.019_bib0025 article-title: Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.11.006 contributor: fullname: Sánchez-Lamar – volume: 32 start-page: 1 issue: 8 year: 2018 ident: 10.1016/j.phymed.2018.12.019_bib0024 article-title: Phytotherapeutics in cancer invasion and metastasis publication-title: Phytother. Res. doi: 10.1002/ptr.6087 contributor: fullname: Salehi – volume: 38 start-page: 547 issue: 4 year: 2013 ident: 10.1016/j.phymed.2018.12.019_bib0034 article-title: (-) Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells publication-title: J. Toxicol. Sci. doi: 10.2131/jts.38.547 contributor: fullname: Takeda – volume: 28 start-page: 824 issue: 4 year: 2011 ident: 10.1016/j.phymed.2018.12.019_bib0037 article-title: Xanthane sesquiterpenoids: structure, synthesis and biological activity publication-title: Nat. Prod. Rep. doi: 10.1039/c0np00011f contributor: fullname: Vasas – volume: 25 start-page: 1883 issue: 12 year: 2011 ident: 10.1016/j.phymed.2018.12.019_bib0019 article-title: Biological activities of xanthatin from Xanthium strumarium leaves publication-title: Phytother. Res. doi: 10.1002/ptr.3651 contributor: fullname: Nibret – volume: 8 start-page: 10355 issue: 9 year: 2015 ident: 10.1016/j.phymed.2018.12.019_bib0038 article-title: Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells publication-title: Int. J. Clin. Exp. Pathol. contributor: fullname: Yu – volume: 78 start-page: 890 issue: 9 year: 2012 ident: 10.1016/j.phymed.2018.12.019_bib0040 article-title: Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells publication-title: Planta Med. doi: 10.1055/s-0031-1298481 contributor: fullname: Zhang – volume: 85 start-page: 1160 issue: 11 year: 2007 ident: 10.1016/j.phymed.2018.12.019_bib0022 article-title: Xanthatin and xanthinosin from the burs of Xanthium strumarium L. as potential anticancer agents publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/Y07-104 contributor: fullname: Ramirez-Erosa |
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| Snippet | Colorectal cancer is one of the most common malignancies worldwide and is associated with high mortality rates. We previously reported that Xanthium strumarium... |
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| SubjectTerms | Animals Anti-metastatic Anti-mitotic Anti-proliferative Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Drug Screening Assays, Antitumor Furans - pharmacology Male Mice, Inbred BALB C Mitosis - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Xanthatins Xanthium - chemistry Xanthium strumarium |
| Title | Xanthium strumarium´s xanthatins induces mitotic arrest and apoptosis in CT26WT colon carcinoma cells |
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