Acylhydrazone Derivative A5 Promotes Neurogenesis by Up-Regulating Neurogenesis-Related Genes and Inhibiting Cell-Cycle Progression in Neural Stem/Progenitor Cells

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 14; p. 3330
• Main Authors: Xiang, Xiaoliang, Jiang, Xia, Lin, Hongwei, Yu, Meixing, Wu, Liming, Zhou, Rong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.07.2024
• Subjects: acylhydrazone derivative; Cell cycle; Cell division; Cell growth; Chromosomes; Gene expression; Morphology; Nervous system; neural stem/progenitor cells; Neurodegeneration; Neurogenesis; Neurons; Stem cells; Systems development; neurogenesis; cell cycle; neural stem/progenitor cells; acylhydrazone derivative

Adult neurogenesis involves the generation of functional neurons from neural progenitor cells, which have the potential to complement and restore damaged neurons and neural circuits. Therefore, the development of drugs that stimulate neurogenesis represents a promising strategy in stem cell therapy...