Resting-state network connectivity changes in drug-naive Parkinson’s disease patients with probable REM sleep behavior disorder

• Published in: Journal of Neural Transmission Vol. 130; no. 1; pp. 43 - 51
• Main Authors: De Micco, Rosa, Piramide, Noemi, Di Nardo, Federica, Siciliano, Mattia, Cirillo, Mario, Russo, Antonio, Silvestro, Marcello, Tedeschi, Gioacchino, Esposito, Fabrizio, Tessitore, Alessandro
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.01.2023
• Subjects: Brain Mapping; Cognitive Dysfunction - complications; Cognitive Dysfunction - etiology; Humans; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Neurology; Neurology and Preclinical Neurological Studies - Original Article; Neurosciences; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Psychiatry; REM Sleep Behavior Disorder - diagnostic imaging; Drug-naïve; REM sleep behavior disorders; MRI; Parkinson’s disease; Resting-state connectivity

Epidemiological studies have shown that Parkinson’s disease (PD) patients with probable REM sleep behavior disorder (pRBD) present an increased risk of worse cognitive progression over the disease course. The aim of this study was to investigate, using resting-state functional MRI (RS-fMRI), the fun...