Adenosine Triphosphate - Binding Cassette Transporter A1 gene polymorphism (rs1800977 and rs2230806) analysis in Oral Premalignant Disorder of South Indian Cohort

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 26; no. 3; pp. 1009 - 1016
• Main Authors: Subbiah, Usha, Sivakumar, Kaniha
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.03.2025
• Subjects: Adult; ATP Binding Cassette Transporter 1 - genetics; Case-Control Studies; Female; Follow-Up Studies; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; India - epidemiology; Leukoplakia, Oral - epidemiology; Leukoplakia, Oral - genetics; Leukoplakia, Oral - pathology; Male; Middle Aged; Mouth Neoplasms - epidemiology; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Oral Submucous Fibrosis - epidemiology; Oral Submucous Fibrosis - genetics; Oral Submucous Fibrosis - pathology; Polymorphism, Single Nucleotide - genetics; Precancerous Conditions - epidemiology; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Prognosis; India; ATP binding cassette subfamily A member 1; variant; Single nucleotide polymorphism; leukoplakia; Oral premalignancy disorder

To evaluate the association between the ABCA1 upstream variant rs1800977 (G/A) and the missense variant rs2230806 (C/T) with oral premalignancies such as oral submucous fibrosis and leucoplakia. The rs1800977 and rs2230806 of ABCA1 were analysed using PCR-RFLP in 350 subjects including OSMF, leukopl...