Glycogen synthase kinase-3β/β-catenin signaling in the rat hypothalamus during the estrous cycle

• Published in: Journal of neuroscience research Vol. 90; no. 5; pp. 1078 - 1084
• Main Authors: Barrera-Ocampo, Alvaro, Gutierrez-Vargas, Johanna, Garcia-Segura, Luis Miguel, Cardona-Gómez, Gloria Patricia
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2012
• Subjects: Analysis of Variance; Animals; beta Catenin - metabolism; Disks Large Homolog 4 Protein; Estrous Cycle - physiology; Female; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; GSK3β; Hypothalamus - metabolism; Immunoprecipitation; Intracellular Signaling Peptides and Proteins - metabolism; Membrane Proteins - metabolism; Phosphorylation; PI3K; PSD95; Rats; Rats, Wistar; Signal Transduction - physiology; synapsin I; Synapsins - metabolism; β-catenin

During the estrous cycle, a remodeling of synapses on somas and dendritic spines occurs in the rat hypothalamic arcuate nucleus. The synaptic remodeling is known to be induced by estradiol, but the molecular mechanisms involved still have not been fully clarified. β‐Catenin is known to regulate syna...