Novel Complex of Zinc (II) Dichloroethylenediamine: Synthesis, Characterization, In-silico, and In-vitro Evaluation against Cervical Cancer Cells

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 24; no. 12; pp. 4155 - 4165
• Main Authors: Raya, Indah, Kartina, Desy, Wijaya, Ronald Ivan, Irfandi, Rizal, Abdalrazaq, Eid A, Prihantono, Prihantono, Santi, Santi, Pratiwi, Eka, Khaerunnisa, Andi Besse, Luthfiana, Dewi, Musa, Bulkis, Natsir, Hasnah, Maming, Maming, Zainuddin, Zaraswati Dwyana, Ramlawati, Ramlawati, Fudholi, Ahmad, Usman, Andi Nilawati, Supratman, Unang, Mazaya, Maulida, Sufiandi, Sandi
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.12.2023
• Subjects: Antineoplastic Agents - chemistry; Cervix Uteri - metabolism; DNA; Female; HeLa Cells; Humans; Ligands; Molecular Docking Simulation; Spectroscopy, Fourier Transform Infrared; Uterine Cervical Neoplasms - drug therapy; Zinc - pharmacology; HeLa cells; Zn(en)Cl2; Molecular docking; IC50; Molecular Dynamic

Cervical cancer is a malignancy originating from the cervix and often caused by oncogenic Human Papilloma Virus (HPV), specifically subtypes 16 and 18. Anticancer drugs are chemotherapeutic compounds used for cancer treatment. Therefore, this research aims to synthesize and characterize Zinc (II) di...