Enhanced negative modulation of urotensin II on cardiac function and [Ca2+]i regulation in a diabetic rat model: Insights into molecular and cellular mechanisms

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 392; no. 6; p. 103594
• Main Authors: Zhang, Xiaowei, Chen, Zhe, Cao, Jing, Zhou, Peng, Zhang, Zhi, Sun, Xiaoqiang, Liu, Yixi, Li, Tiankai, Cheng, Heng-Jie, Cheng, Che Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2025
• Subjects: Animals; Calcium - metabolism; Calcium handling; Cardiomyocytes; Contractility; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - physiopathology; Male; Myocardial Contraction - drug effects; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled - metabolism; Urotensin II; Urotensins - metabolism; Urotensins - pharmacology; ICa,L; τ; VES; DM; EES/EA; LV; SA; dV/dtmax; P; PTX; V; dL/dtmax; STZ; Urotensin II; EA; UT; EF; SV; SW; Diabetes mellitus; Contractility; Cardiomyocytes; dR/dtmax; PED; DCM; MSW; EES; UII; VED; Db-cAMP; Calcium handling; [Ca2+]iT; HF; PES

The direct cardiac effects of urotensin II (UII) in normal and diabetic subjects remain controversial. The alteration and functional significance of cardiac UII/UII receptor (UT) in diabetes are still unclear. We assessed the hypothesis that in diabetes, the cardiomyocyte UII/UT system is increased....