Spectroscopic studies of the interaction of bichromophoric cyanine dyes with DNA. Effect of ionic strength
Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is ch...
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| Published in | Biochimica et biophysica acta Vol. 1621; no. 2; pp. 183 - 191 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
02.05.2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/S0304-4165(03)00057-6 |
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| Abstract | Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is characterized by intense optical absorption (
ε=1.33×10
5 M
−1 cm
−1) and weak fluorescence (
ϕ
fl=0.018) in the wavelength region greater than 600 nm. The dye forms H-aggregates at low concentrations (10
−6 M). NaCl stimulates the formation of both H- and J-aggregates of the dye at much lower dye concentrations, while DNA in low concentrations (<10
−6 M) stimulated the formation of just J-aggregates on the surface of the DNA molecule. Higher DNA concentrations induce the dye to disaggregate, and there exists an equilibrium between three dye forms: free monomers, J-aggregates and bound monomers, the maximum content of J-aggregates was observed at [DNA]/[BCD]=0.6±0.2 and total disaggregation at [DNA]/[BCD]=190±20. J-aggregates are characterized by
ϕ
fl=0.05 and bound monomers by
ϕ
fl=0.44. In the presence of NaCl, total disaggregation was observed at [DNA]/[BCD]=570±10 due to competition between Na
+ and the dye molecules for DNA electronegative binding sites. |
|---|---|
| AbstractList | Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is characterized by intense optical absorption (
ε=1.33×10
5 M
−1 cm
−1) and weak fluorescence (
ϕ
fl=0.018) in the wavelength region greater than 600 nm. The dye forms H-aggregates at low concentrations (10
−6 M). NaCl stimulates the formation of both H- and J-aggregates of the dye at much lower dye concentrations, while DNA in low concentrations (<10
−6 M) stimulated the formation of just J-aggregates on the surface of the DNA molecule. Higher DNA concentrations induce the dye to disaggregate, and there exists an equilibrium between three dye forms: free monomers, J-aggregates and bound monomers, the maximum content of J-aggregates was observed at [DNA]/[BCD]=0.6±0.2 and total disaggregation at [DNA]/[BCD]=190±20. J-aggregates are characterized by
ϕ
fl=0.05 and bound monomers by
ϕ
fl=0.44. In the presence of NaCl, total disaggregation was observed at [DNA]/[BCD]=570±10 due to competition between Na
+ and the dye molecules for DNA electronegative binding sites. Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is characterized by intense optical absorption (epsilon =1.33 x 10(5) M(-1) x cm(-1)) and weak fluorescence (phi(fl)=0.018) in the wavelength region greater than 600 nm. The dye forms H-aggregates at low concentrations (10(-6) M). NaCl stimulates the formation of both H- and J-aggregates of the dye at much lower dye concentrations, while DNA in low concentrations (<10(-6) M) stimulated the formation of just J-aggregates on the surface of the DNA molecule. Higher DNA concentrations induce the dye to disaggregate, and there exists an equilibrium between three dye forms: free monomers, J-aggregates and bound monomers, the maximum content of J-aggregates was observed at [DNA]/[BCD]=0.6+/-0.2 and total disaggregation at [DNA]/[BCD]=190+/-20. J-aggregates are characterized by phi(fl)=0.05 and bound monomers by phi(fl)=0.44. In the presence of NaCl, total disaggregation was observed at [DNA]/[BCD]=570+/-10 due to competition between Na(+) and the dye molecules for DNA electronegative binding sites.Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is characterized by intense optical absorption (epsilon =1.33 x 10(5) M(-1) x cm(-1)) and weak fluorescence (phi(fl)=0.018) in the wavelength region greater than 600 nm. The dye forms H-aggregates at low concentrations (10(-6) M). NaCl stimulates the formation of both H- and J-aggregates of the dye at much lower dye concentrations, while DNA in low concentrations (<10(-6) M) stimulated the formation of just J-aggregates on the surface of the DNA molecule. Higher DNA concentrations induce the dye to disaggregate, and there exists an equilibrium between three dye forms: free monomers, J-aggregates and bound monomers, the maximum content of J-aggregates was observed at [DNA]/[BCD]=0.6+/-0.2 and total disaggregation at [DNA]/[BCD]=190+/-20. J-aggregates are characterized by phi(fl)=0.05 and bound monomers by phi(fl)=0.44. In the presence of NaCl, total disaggregation was observed at [DNA]/[BCD]=570+/-10 due to competition between Na(+) and the dye molecules for DNA electronegative binding sites. Spectroscopic characteristics of a cyanine dye with two chromophores (biscyanine dye, BCD) in aqueous solutions and effects of NaCl and DNA upon these characteristics have been studied by optical absorption, circular dichroism (CD) and fluorescence spectroscopies. In homogeneous solutions, BCD is characterized by intense optical absorption (epsilon =1.33 x 10(5) M(-1) x cm(-1)) and weak fluorescence (phi(fl)=0.018) in the wavelength region greater than 600 nm. The dye forms H-aggregates at low concentrations (10(-6) M). NaCl stimulates the formation of both H- and J-aggregates of the dye at much lower dye concentrations, while DNA in low concentrations (<10(-6) M) stimulated the formation of just J-aggregates on the surface of the DNA molecule. Higher DNA concentrations induce the dye to disaggregate, and there exists an equilibrium between three dye forms: free monomers, J-aggregates and bound monomers, the maximum content of J-aggregates was observed at [DNA]/[BCD]=0.6+/-0.2 and total disaggregation at [DNA]/[BCD]=190+/-20. J-aggregates are characterized by phi(fl)=0.05 and bound monomers by phi(fl)=0.44. In the presence of NaCl, total disaggregation was observed at [DNA]/[BCD]=570+/-10 due to competition between Na(+) and the dye molecules for DNA electronegative binding sites. |
| Author | Schaberle, Fábio A. Borissevitch, Iouri E. Kuz'min, Vladimir A. |
| Author_xml | – sequence: 1 givenname: Fábio A. surname: Schaberle fullname: Schaberle, Fábio A. organization: Departamento de Fı́sica e Matemática, Faculdade de Filosofia Ciência e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Vila Monte Alegre, CEP 14040-901, Ribeirão Preto, SP, Brazil – sequence: 2 givenname: Vladimir A. surname: Kuz'min fullname: Kuz'min, Vladimir A. organization: Emanuel Institute of Biochemical Physics, Russian Academy of Science, Kosygin st. 4, 117977, Moscow, Russia – sequence: 3 givenname: Iouri E. surname: Borissevitch fullname: Borissevitch, Iouri E. email: iouri@dfm.ffclrp.usp.br, iourib@ffclrp.usp.br organization: Departamento de Fı́sica e Matemática, Faculdade de Filosofia Ciência e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Vila Monte Alegre, CEP 14040-901, Ribeirão Preto, SP, Brazil |
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| Keywords | Photodynamic therapy Ionic strength DNA Bichromophoric cyanine dye |
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| SubjectTerms | Bichromophoric cyanine dye Carbocyanines - chemistry Chromogenic Compounds - chemistry Circular Dichroism DNA DNA - chemistry Ionic strength Osmolar Concentration Photochemotherapy Photodynamic therapy Sodium Chloride - pharmacology Spectrometry, Fluorescence |
| Title | Spectroscopic studies of the interaction of bichromophoric cyanine dyes with DNA. Effect of ionic strength |
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