Coxiella burnetii protein CBU2016 supports CCV expansion

• Published in: Pathogens and disease Vol. 82
• Main Authors: Thomas, David R, Garnish, Sarah E, Khoo, Chen Ai, Padmanabhan, Bhavna, Scott, Nichollas E, Newton, Hayley J
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 07.02.2024
• Subjects: Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cell Line; Coxiella burnetii - genetics; Coxiella burnetii - metabolism; Coxiella burnetii - pathogenicity; Gene Knockout Techniques; HeLa Cells; Host-Pathogen Interactions; Humans; Moths - microbiology; Q Fever - microbiology; THP-1 Cells; Vacuoles - metabolism; Vacuoles - microbiology; Virulence Factors - genetics; Virulence Factors - metabolism; Dot/Icm secretion system; replicative vacuole; Coxiella burnetii; intracellular bacterial pathogen

Coxiella burnetii is a globally distributed obligate intracellular pathogen. Although often asymptomatic, infections can cause acute Q fever with influenza-like symptoms and/or severe chronic Q fever. Coxiella burnetii develops a unique replicative niche within host cells called the Coxiella-contain...