PAMAM Dendrimers Conjugated with L-Arginine and γ-Aminobutyric Acid as Novel Polymeric Gene Delivery Carriers

• Published in: Bulletin of the Korean Chemical Society Vol. 34; no. 2; pp. 579 - 584
• Main Authors: Son, Sang Jae, Yu, Gwang Sig, Choe, Yun Hui, Kim, Youn-Joong, Lee, Eunji, Park, Jong-Sang, Choi, Joon Sig
• Format: Journal Article
• Language: English
• Published: 대한화학회 20.02.2013
• Subjects: 화학

In this study, we synthesized functional dendrimer derivatives as nonviral gene delivery vectors. Poly(amidoamine) dendrimer (PAMAM, generation 4) was modified to possess functional amino acids to enhance gene transfection efficiency. PAMAM G4 derivatives conjugated with L-arginine (Arg) and γ-amino...