Effect of efonidipine hydrochloride (NZ-105), a dihydropyridine derivative with calcium antagonistic action, on myocardial oxygen tension in anesthetized dogs

• Published in: Nihon yakurigaku zasshi Vol. 108; no. 5; p. 267
• Main Authors: Fujikura, N, Yokoyama, T, Masuda, Y, Shikada, K, Tanaka, S
• Format: Journal Article
• Language: Japanese
• Published: Japan 1996
• Subjects: Animals; Blood Pressure - drug effects; Calcium Channel Blockers - pharmacology; Coronary Circulation - drug effects; Dihydropyridines - pharmacology; Dogs; Myocardium - metabolism; Nifedipine - pharmacology; Nisoldipine - pharmacology; Nitrophenols; Organophosphorus Compounds - pharmacology; Oxygen Consumption - drug effects; Partial Pressure

Effect of efonidipine hydrochloride (efonidipine) on myocardial oxygen tension (PO2) was investigated in open-chest anesthetized dog and compared with those of nifedipine and nisoldipine. PO2 was measured by a membrane-coated platinum wire, which was inserted into the myocardium. Intravenous adminis...