The influence of Escherichia coli Hfq mutations on RNA binding and sRNA•mRNA duplex formation in rpoS riboregulation

• Published in: Biochimica et biophysica acta Vol. 1809; no. 10; pp. 532 - 540
• Main Authors: Updegrove, Taylor B., Wartell, Roger M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2011
• Subjects: Bacterial Proteins - genetics; DsrA; Escherichia coli - genetics; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Gene Expression Regulation, Bacterial; Hfq protein; Host Factor 1 Protein - genetics; Kinetics; Mutation; OxyS; Protein Binding; Protein Biosynthesis; Protein Conformation; Protein Structure, Tertiary; Repressor Proteins - genetics; RNA, Bacterial - genetics; RNA, Messenger - genetics; RprA; Sigma Factor - genetics; sRNA–rpoS mRNA regulation; sRNA–rpoS mRNA regulation; Hfq protein; RprA; OxyS; DsrA

The Escherichia coli RNA binding protein Hfq plays an important role in regulating mRNA translation through its interactions with small non-coding RNAs (sRNAs) and specific mRNAs sites. The rpoS mRNA, which codes for a transcription factor, is regulated by several sRNAs. DsrA and RprA enhance transl...