rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid

• Published in: MolBank Vol. 2022; no. 3; p. M1410
• Main Authors: Yushyn, Ihor, Holota, Serhii, Ivantsiv, Oksana, Lesyk, Roman
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2022
• Subjects: Acetic acid; Acids; acylation; Anticancer properties; Cancer; Carbon; Carbonyls; Diels-Alder reactions; Ethanol; hetero-Diels–Alder reaction; Leukemia; Melanoma; NMR; Nuclear magnetic resonance; pyrazoline; Synthesis; thiopyrano[2,3-d]thiazoles; United States > US

The hetero-Diels–Alder reaction is the main synthetic tool for obtaining pharmacological agents with a thiopyrano[2,3-d]thiazole motif. In the present work, an efficient method for the synthesis of pyrazoline-containing thiopyrano[2,3-d]thiazole is described. The pyrazoline-bearing dienophile was pr...