Amlodipine, an L-type Ca2+ channel inhibitor, regulates release of extracellular vesicles from tumor cells

• Published in: Carcinogenesis (New York) Vol. 46; no. 2
• Main Authors: Mondal, Sujan K, Hong, Chang-Sook, Han, Jie, Diergaarde, Brenda, Zandberg, Dan P, Whiteside, Theresa L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 03.04.2025
• Subjects: Amlodipine - pharmacology; Animals; Autophagy - drug effects; Calcium Channel Blockers - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Exosomes - drug effects; Exosomes - metabolism; Extracellular Vesicles - drug effects; Extracellular Vesicles - metabolism; Female; Humans; Inflammation, Tumor Microenvironment and Cancer Immunology; Mice; Neoplasms - drug therapy; Neoplasms - pathology; tumor growth; cancer; autocrine effects; extracellular vesicles; amlodipine

Tumor cells produce/release tumor-derived exosomes (TEX) which promote tumor growth, drive immune suppression, and interfere with immune therapies. Amlodipine, a calcium flux inhibitor, may block TEX release by tumor cells. Amlodipine’s potential as a drug blocking TEX release was evaluated. We meas...