Cutting Edge: Anti-CD1 Monoclonal Antibody Treatment Reverses the Production Patterns of TGF-β2 and Th1 Cytokines and Ameliorates Listeriosis in Mice
Abstract Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I g...
Saved in:
Published in | The Journal of immunology (1950) Vol. 162; no. 12; pp. 6955 - 6958 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
15.06.1999
|
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-β2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-γ at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis. |
---|---|
AbstractList | Abstract
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-β2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-γ at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis. |
Author | Szalay, Gudrun Blum, Carmen Ladel, Christoph H. Kaufmann, Stefan H. E. Kronenberg, Mitchell Brossay, Laurent |
Author_xml | – sequence: 1 givenname: Gudrun surname: Szalay fullname: Szalay, Gudrun – sequence: 2 givenname: Christoph H. surname: Ladel fullname: Ladel, Christoph H. – sequence: 3 givenname: Carmen surname: Blum fullname: Blum, Carmen – sequence: 4 givenname: Laurent surname: Brossay fullname: Brossay, Laurent – sequence: 5 givenname: Mitchell surname: Kronenberg fullname: Kronenberg, Mitchell – sequence: 6 givenname: Stefan H. E. surname: Kaufmann fullname: Kaufmann, Stefan H. E. |
BookMark | eNo1kEtOwzAYhC0EEm3hBix8gQQ_EqdhV4W2ILWiQmEdOc6f1iWxke0i9SIchINwJlIeq9GM9M3iG6NzYw0gdENJnJAkv93rvj8Y28VUsJiyWORpeoZGNE1JJAQR52hECGMRzUR2icbe7wkhgrBkhD6KQwjabPG82cIdnpmgo-Ke4rU1VnXWyO5nq21zxKUDGXowAT_DOzgPHocd4I2zzUEFbQ3eyBDAGY9ti8vlIvr6ZFiaBpc7iotjsK_aDNBpmfXQaetkGPpK-4HS1muPtcFrreAKXbSy83D9lxP0spiXxUO0elo-FrNVpFgm0ggSJWXeqjajlKhUCpKQaU1rUCzngvOEThnluUgFl7XgTc6BQ11D3cqpkDLlE5T8_ipnvXfQVm9O99IdK0qqk9vq3201uK0oq05u-TdUQnPk |
CitedBy_id | crossref_primary_10_1002_eji_200425846 crossref_primary_10_4049_jimmunol_166_3_1755 crossref_primary_10_1002_med_21276 crossref_primary_10_4049_jimmunol_0800924 crossref_primary_10_1128_IAI_00311_06 crossref_primary_10_1097_SHK_0b013e31829ca519 crossref_primary_10_4049_jimmunol_180_7_4371 crossref_primary_10_1099_jmm_0_47747_0 crossref_primary_10_1007_s002810000042 crossref_primary_10_4049_jimmunol_168_1_365 crossref_primary_10_1172_JCI200317165 crossref_primary_10_1002_art_21056 crossref_primary_10_1016_j_smim_2009_10_006 crossref_primary_10_1111_j_1365_2567_2003_01779_x crossref_primary_10_4049_jimmunol_177_11_7841 crossref_primary_10_1016_S1873_9598_08_70025_5 crossref_primary_10_1007_s10875_005_8064_5 crossref_primary_10_1016_S0022_1759_00_00321_5 crossref_primary_10_1111_j_1600_0757_2006_00173_x crossref_primary_10_1073_pnas_97_15_8461 crossref_primary_10_1016_j_micinf_2005_07_002 crossref_primary_10_3314_mmj_55_J115 crossref_primary_10_4049_jimmunol_165_9_4797 crossref_primary_10_1006_smim_2000_0272 crossref_primary_10_4049_jimmunol_172_1_186 crossref_primary_10_1016_S0165_6147_00_01476_0 crossref_primary_10_1007_s11046_011_9451_5 crossref_primary_10_1111_j_0818_9641_2004_01264_x crossref_primary_10_1016_S1286_4579_99_00248_8 crossref_primary_10_1016_S1286_4579_01_01485_X crossref_primary_10_1128_CMR_00232_20 crossref_primary_10_1016_j_jaci_2010_01_018 crossref_primary_10_1016_S0966_842X_00_01829_1 crossref_primary_10_1111_j_1600_065X_2010_00993_x crossref_primary_10_1189_jlb_69_5_713 crossref_primary_10_1111_j_1348_0421_2002_tb02687_x crossref_primary_10_4049_jimmunol_164_10_5000 crossref_primary_10_3389_fimmu_2015_00362 crossref_primary_10_1016_S1286_4579_00_00363_4 crossref_primary_10_1517_14728222_2011_584874 crossref_primary_10_1002_hep_20433 crossref_primary_10_1128_IAI_01091_08 crossref_primary_10_1371_journal_ppat_1000239 crossref_primary_10_1016_S0047_6374_00_00194_9 crossref_primary_10_1016_j_imlet_2011_04_012 crossref_primary_10_1053_j_gastro_2008_10_027 crossref_primary_10_4049_jimmunol_167_11_6525 crossref_primary_10_4049_jimmunol_169_2_906 crossref_primary_10_1016_j_micinf_2008_07_018 crossref_primary_10_1016_S0165_2478_01_00310_8 crossref_primary_10_3349_ymj_2009_50_1_12 crossref_primary_10_1080_713608012 crossref_primary_10_1146_annurev_immunol_22_012703_104608 crossref_primary_10_4049_jimmunol_175_2_1137 crossref_primary_10_1016_j_micinf_2013_08_006 crossref_primary_10_1002_eji_200324254 crossref_primary_10_1016_j_vaccine_2006_05_093 crossref_primary_10_1111_j_1365_3024_2006_00898_x crossref_primary_10_1128_IAI_71_10_5447_5455_2003 crossref_primary_10_1128_IAI_73_1_181_192_2005 crossref_primary_10_1084_jem_190_9_1197 crossref_primary_10_1371_journal_pone_0097701 crossref_primary_10_1038_nrmicro1657 crossref_primary_10_1128_IAI_72_9_5175_5180_2004 crossref_primary_10_1084_jem_191_6_937 |
Cites_doi | 10.1146/annurev.immunol.16.1.137 10.4049/jimmunol.159.5.2240 10.1126/science.7542404 10.1016/S1074-7613(00)80289-7 10.1128/iai.64.9.3901-3904.1996 10.4049/jimmunol.158.10.4846 10.1016/S1074-7613(00)80533-6 10.1111/j.1600-065X.1997.tb00995.x 10.4049/jimmunol.160.8.3681 10.1111/j.1600-065X.1995.tb00086.x 10.4049/jimmunol.160.7.3121 10.4049/jimmunol.157.11.4746 10.1016/0952-7915(95)80112-X 10.1016/0092-8674(92)90097-V 10.1111/j.1600-065X.1995.tb00085.x 10.4049/jimmunol.157.2.574 10.4049/jimmunol.159.3.1216 10.4049/jimmunol.161.11.6148 10.1016/S1074-7613(00)80290-3 10.1126/science.7538697 10.1038/372691a0 10.4049/jimmunol.160.4.1589 |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.4049/jimmunol.162.12.6955 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Biology |
EISSN | 1550-6606 |
EndPage | 6958 |
ExternalDocumentID | 10_4049_jimmunol_162_12_6955 |
GroupedDBID | --- -~X .55 .GJ 18M 2WC 34G 39C 3O- 53G 5GY 5RE 5VS 79B 85S AARDX AAYXX ABCQX ABEFU ABJNI ABOCM ABPPZ ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADNWM AENEX AFFNX AFHIN AFOSN AFRAH AHWXS AI. AIZAD ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW CITATION D0L DIK DU5 E3Z EBS EJD F5P FRP G8K GX1 IH2 J5H K-O KQ8 L7B MVM NEJ OK1 P0W P2P PQQKQ R.V RHF RHI RZQ SJN TR2 TWZ VH1 W8F WH7 WOQ X7M XJT XSW XTH YCJ YHG ZE2 ZGI ZXP |
ID | FETCH-LOGICAL-c2765-e4caa9fcf7110c5a60408b1bec29363341821396563ab63d93e3ebbebfa86aa53 |
ISSN | 0022-1767 |
IngestDate | Thu Sep 26 16:08:59 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c2765-e4caa9fcf7110c5a60408b1bec29363341821396563ab63d93e3ebbebfa86aa53 |
OpenAccessLink | https://journals.aai.org/jimmunol/article-pdf/162/12/6955/1101510/im129906955p.pdf |
PageCount | 4 |
ParticipantIDs | crossref_primary_10_4049_jimmunol_162_12_6955 |
PublicationCentury | 1900 |
PublicationDate | 1999-06-15 |
PublicationDateYYYYMMDD | 1999-06-15 |
PublicationDate_xml | – month: 06 year: 1999 text: 1999-06-15 day: 15 |
PublicationDecade | 1990 |
PublicationTitle | The Journal of immunology (1950) |
PublicationYear | 1999 |
References | 2022123017354459100_R9 2022123017354459100_R8 2022123017354459100_R7 2022123017354459100_R6 2022123017354459100_R5 2022123017354459100_R4 2022123017354459100_R3 2022123017354459100_R16 2022123017354459100_R2 2022123017354459100_R15 2022123017354459100_R1 2022123017354459100_R18 2022123017354459100_R17 2022123017354459100_R19 2022123017354459100_R10 2022123017354459100_R21 2022123017354459100_R20 2022123017354459100_R12 2022123017354459100_R23 2022123017354459100_R11 2022123017354459100_R22 2022123017354459100_R14 2022123017354459100_R13 |
References_xml | – ident: 2022123017354459100_R16 doi: 10.1146/annurev.immunol.16.1.137 – ident: 2022123017354459100_R21 doi: 10.4049/jimmunol.159.5.2240 – ident: 2022123017354459100_R5 doi: 10.1126/science.7542404 – ident: 2022123017354459100_R10 doi: 10.1016/S1074-7613(00)80289-7 – ident: 2022123017354459100_R15 doi: 10.1128/iai.64.9.3901-3904.1996 – ident: 2022123017354459100_R22 doi: 10.4049/jimmunol.158.10.4846 – ident: 2022123017354459100_R19 doi: 10.1016/S1074-7613(00)80533-6 – ident: 2022123017354459100_R8 doi: 10.1111/j.1600-065X.1997.tb00995.x – ident: 2022123017354459100_R17 doi: 10.4049/jimmunol.160.8.3681 – ident: 2022123017354459100_R6 doi: 10.1111/j.1600-065X.1995.tb00086.x – ident: 2022123017354459100_R13 doi: 10.4049/jimmunol.160.7.3121 – ident: 2022123017354459100_R14 doi: 10.4049/jimmunol.157.11.4746 – ident: 2022123017354459100_R9 doi: 10.1016/0952-7915(95)80112-X – ident: 2022123017354459100_R2 doi: 10.1016/0092-8674(92)90097-V – ident: 2022123017354459100_R3 doi: 10.1111/j.1600-065X.1995.tb00085.x – ident: 2022123017354459100_R23 doi: 10.4049/jimmunol.157.2.574 – ident: 2022123017354459100_R7 doi: 10.4049/jimmunol.159.3.1216 – ident: 2022123017354459100_R18 doi: 10.4049/jimmunol.161.11.6148 – ident: 2022123017354459100_R11 doi: 10.1016/S1074-7613(00)80290-3 – ident: 2022123017354459100_R1 – ident: 2022123017354459100_R12 doi: 10.1126/science.7538697 – ident: 2022123017354459100_R4 doi: 10.1038/372691a0 – ident: 2022123017354459100_R20 doi: 10.4049/jimmunol.160.4.1589 |
SSID | ssj0006024 |
Score | 1.9372073 |
Snippet | Abstract
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC... |
SourceID | crossref |
SourceType | Aggregation Database |
StartPage | 6955 |
Title | Cutting Edge: Anti-CD1 Monoclonal Antibody Treatment Reverses the Production Patterns of TGF-β2 and Th1 Cytokines and Ameliorates Listeriosis in Mice |
Volume | 162 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LjtMwFLXKIBAbBANoeMoLuqpSUidxEnYzmQ7lMWgEGWl2kZ04oqKToCpZdD6ED-FD-BC-gnvjPFxUIYZN1VrtVZt7al_fnHNMyEtY8lJX-aJpL1kuy0NLeKlruZxlIgu8lNuoHT79yBfn7rsL72I0-mWwlupKTtOrnbqS_8kqjEFeUSV7jcz2QWEAnkN-4REyDI__lOOo1qzlOR6Q3nT4qqUVHc_wn1qmq6bJh2OyzDaTuKeUf1LIxUBvB8DImbZ8RRScNV6bmhcXvzmxxtF8fMRYc38h_jKbRJuq_Io0-Wbk8FKtUN-PjdsPCJb1skR3k2WBXPwthtGgP9MWFahJ0d5P4-YOm230Iz5fiZXQ8pk6W9cDYwj9LLfsECaLad9MaI9rjsT6ctC2HWEFoGOh_Luj-GSt6A99ESyt8jQ0BzNfH9wxVe1U7cHGl9t8ay7nzAQtM6ZmHmo_4HaZh5fBriXEhS0TLiHtpZhCROwXD582Hbv_WEl7fiPsrDBO0kVJIEoyYwlGuUFuMj_0sFFw_PZ9XzVwm7mdsz3-Ui3zxCivdn0Xo4wy6qH4HrnbppMealTeJyNV7JNb-mjTzT65fdqSNh6Q7y1MKcL0Ne1ASgeQ0g6ktAcp7UBKAaR0ACntQErLnCJIf_5gFOBIAaC0B2gzYgCUGgCly4IiQB-S85N5HC2s9jgQK2U-9yzlpkKEeZr7ULKmnuCw_gRyBpMQlKzcgXIsYLCfgQ2KIyR3stBRjpJSyVwEXAjPeUT2irJQB4R6UsgcKuuAObmrQl_wMFSBrWzHzT0ZZI-J1V3d5Jt2fUn-ltMn13z_U3JngPkzsleta_UcittKvmhQ8Rtod6cf |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cutting+Edge%3A+Anti-CD1+Monoclonal+Antibody+Treatment+Reverses+the+Production+Patterns+of+TGF-%CE%B22+and+Th1+Cytokines+and+Ameliorates+Listeriosis+in+Mice&rft.jtitle=The+Journal+of+immunology+%281950%29&rft.au=Szalay%2C+Gudrun&rft.au=Ladel%2C+Christoph+H.&rft.au=Blum%2C+Carmen&rft.au=Brossay%2C+Laurent&rft.date=1999-06-15&rft.issn=0022-1767&rft.eissn=1550-6606&rft.volume=162&rft.issue=12&rft.spage=6955&rft.epage=6958&rft_id=info:doi/10.4049%2Fjimmunol.162.12.6955&rft.externalDBID=n%2Fa&rft.externalDocID=10_4049_jimmunol_162_12_6955 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1767&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1767&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1767&client=summon |