CREB activates the MafA promoter through proximal E-boxes and a CCAAT motif in pancreatic β-cells

• Published in: Journal of molecular endocrinology Vol. 73; no. 3; p. 1
• Main Authors: Aida, Yuki, Kataoka, Kohsuke
• Format: Journal Article
• Language: English
• Published: England Society for Endocrinology & BioScientifica Ltd 01.10.2024
• Subjects: Animal models; Beta cells; Beta2 protein; Cell culture; Cyclic AMP response element-binding protein; Diabetes mellitus (non-insulin dependent); Genomic analysis; Glucose transporter; Insulin secretion; Islet-1 protein; Pancreas; Preproinsulin; Regulatory sequences; Transcription activation; Transcription factors

MafA is a key transcriptional regulator of pancreatic islet β-cell function. Its target genes include those encoding preproinsulin and the glucose transporter Glut2 ( Slc2a2 ); thus, MafA function is essential for glucose-stimulated insulin secretion. Expression levels of MafA are reduced in β-cells...