Combined external beam and intracavitary radiotherapy in oesophageal carcinoma
Seventy patients (40 males, 30 female; age 36–87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre, Newcastle General Hospital with oesophageal carcinoma (54 squamous cell; tumour length 2–14 cm). Sixty-seven patients received combined external...
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| Published in | Clinical oncology (Royal College of Radiologists (Great Britain)) Vol. 4; no. 4; pp. 222 - 227 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
1992
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| Subjects | |
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| Abstract | Seventy patients (40 males, 30 female; age 36–87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre, Newcastle General Hospital with oesophageal carcinoma (54 squamous cell; tumour length 2–14 cm). Sixty-seven patients received combined external beam radiotherapy (20–50 Gy in 5–20 fractions over 1–4 weeks) followed by intracavitary radiation (66 patients received 10 Gy at 1 cm; the remaining 4 received less) using an endoscopically inserted afterloading technique at 6.4 Gy/hour.
Swallowing was restored in 65 patients (92%), although 39 patients (55.7%) subsequently required dilatation.
Four developed fistulae (1 day, 2 months, 11 months, 17 months post-treatment). The actuarial survival was 71% at 6 months and 42% at 1 year.
The combined treatment is well tolerated, with few complications and provides good palliation. |
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| AbstractList | Seventy patients (40 males, 30 female; age 36–87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre, Newcastle General Hospital with oesophageal carcinoma (54 squamous cell; tumour length 2–14 cm). Sixty-seven patients received combined external beam radiotherapy (20–50 Gy in 5–20 fractions over 1–4 weeks) followed by intracavitary radiation (66 patients received 10 Gy at 1 cm; the remaining 4 received less) using an endoscopically inserted afterloading technique at 6.4 Gy/hour.
Swallowing was restored in 65 patients (92%), although 39 patients (55.7%) subsequently required dilatation.
Four developed fistulae (1 day, 2 months, 11 months, 17 months post-treatment). The actuarial survival was 71% at 6 months and 42% at 1 year.
The combined treatment is well tolerated, with few complications and provides good palliation. Seventy patients (40 males, 30 female; age 36-87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre, Newcastle General Hospital with oesophageal carcinoma (54 squamous cell; tumour length 2-14 cm). Sixty-seven patients received combined external beam radiotherapy (20-50 Gy in 5-20 fractions over 1-4 weeks) followed by intracavitary radiation (66 patients received 10 Gy at 1 cm; the remaining 4 received less) using an endoscopically inserted afterloading technique at 6.4 Gy/hour. Swallowing was restored in 65 patients (92%), although 39 patients (55.7%) subsequently required dilatation. Four developed fistulae (1 day, 2 months, 11 months, 17 months post-treatment). The actuarial survival was 71% at 6 months and 42% at 1 year. The combined treatment is well tolerated, with few complications and provides good palliation. |
| Author | Clague, M.B. Agrawal, R.K. Dawes, P.J.D.K. |
| Author_xml | – sequence: 1 givenname: R.K. surname: Agrawal fullname: Agrawal, R.K. organization: Department of Clinical Oncology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK – sequence: 2 givenname: P.J.D.K. surname: Dawes fullname: Dawes, P.J.D.K. organization: Department of Clinical Oncology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK – sequence: 3 givenname: M.B. surname: Clague fullname: Clague, M.B. organization: Department of Surgery, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1377931$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0009-9260(66)80030-2 10.1016/S0140-6736(85)90527-6 10.1016/S0167-8140(87)80214-1 10.1148/radiology.159.2.3961189 10.1148/radiology.159.3.3704151 10.1002/bjs.1800670702 10.1016/0360-3016(89)90139-9 10.1007/BF01537405 10.1007/BF02256513 |
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| References | Hishikawa, Tanaka, Miura (bib11) 1986; 159 Love, Berkow (bib10) 1978; 2 Pearson (bib3) 1966; 17 McKeown (bib2) 1979; 24 Rosenberg, Lichtner, Roth (bib4) 1985 Hishikawa, Kamikonya, Tanaka (bib7) 1987; 9 Earlam, Johnson (bib8) 1990; 72 Yin (bib13) 1989; 2 Hishikawa, Kamikonya, Tanaka (bib9) 1986; 159 Flores, Nelems, Evans (bib6) 1989; 17 Earlam, Cunha-Melo (bib1) 1980; 67 Naveau, Chiesa, Poynard (bib12) 1990; 35 Rowland, Pagliero (bib5) 1985; ii Naveau (10.1016/S0936-6555(05)81056-8_bib12) 1990; 35 Hishikawa (10.1016/S0936-6555(05)81056-8_bib9) 1986; 159 Rowland (10.1016/S0936-6555(05)81056-8_bib5) 1985; ii Love (10.1016/S0936-6555(05)81056-8_bib10) 1978; 2 Pearson (10.1016/S0936-6555(05)81056-8_bib3) 1966; 17 Hishikawa (10.1016/S0936-6555(05)81056-8_bib7) 1987; 9 Rosenberg (10.1016/S0936-6555(05)81056-8_bib4) 1985 McKeown (10.1016/S0936-6555(05)81056-8_bib2) 1979; 24 Yin (10.1016/S0936-6555(05)81056-8_bib13) 1989; 2 Earlam (10.1016/S0936-6555(05)81056-8_bib1) 1980; 67 Hishikawa (10.1016/S0936-6555(05)81056-8_bib11) 1986; 159 Flores (10.1016/S0936-6555(05)81056-8_bib6) 1989; 17 Earlam (10.1016/S0936-6555(05)81056-8_bib8) 1990; 72 |
| References_xml | – volume: 2 start-page: 305 year: 1978 end-page: 321 ident: bib10 article-title: Trauma to the oesophagus publication-title: Gastrointest Radiol contributor: fullname: Berkow – start-page: 621 year: 1985 end-page: 657 ident: bib4 article-title: Cancer of the esophagus publication-title: Cancer: principles and practice of oncology contributor: fullname: Roth – volume: 9 start-page: 13 year: 1987 end-page: 20 ident: bib7 article-title: Radiotherapy of esophageal carcinoma. Role of high-dose-rate intracavitary irradiation publication-title: Radiother Oncol contributor: fullname: Tanaka – volume: 72 start-page: 32 year: 1990 end-page: 40 ident: bib8 article-title: 101 oesophageal cancers: a surgeon uses radiotherapy publication-title: Ann R Coll Surg Engl contributor: fullname: Johnson – volume: 17 start-page: 242 year: 1966 end-page: 257 ident: bib3 article-title: The radiotherapy of carcinoma of the oesophagus and post-cricoid region in South East Scotland publication-title: Clin Radiol contributor: fullname: Pearson – volume: ii start-page: 981 year: 1985 end-page: 983 ident: bib5 article-title: Intracavitary irradiation in palliation of carcinoma of oesophagus and cardia publication-title: Lancet contributor: fullname: Pagliero – volume: 17 start-page: 937 year: 1989 end-page: 944 ident: bib6 article-title: Impact of new radiotherapy modalities on surgical management of cancer of the oesophagus and cardia publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Evans – volume: 35 start-page: 294 year: 1990 end-page: 301 ident: bib12 article-title: Endoscopic Nd-YAG laser therapy as palliative treatment for esophageal and cardial cancer publication-title: Dig Dis Sci contributor: fullname: Poynard – volume: 159 start-page: 715 year: 1986 end-page: 716 ident: bib9 article-title: Esophageal stricture following high-dose-rate intracavitary irradiation for esophageal cancer publication-title: Radiology contributor: fullname: Tanaka – volume: 2 start-page: 439 year: 1989 end-page: 441 ident: bib13 article-title: Brachytherapy of carcinoma of the oesophagus in China publication-title: Brachytherapy contributor: fullname: Yin – volume: 67 start-page: 457 year: 1980 end-page: 461 ident: bib1 article-title: Oesophageal squamous cell carcinoma: II. A critical review of radiotherapy publication-title: Br J Surgery contributor: fullname: Cunha-Melo – volume: 159 start-page: 549 year: 1986 end-page: 551 ident: bib11 article-title: Esophageal fistula associated with intracavitary irradiation for esophageal carcinoma publication-title: Radiology contributor: fullname: Miura – volume: 24 start-page: 253 year: 1979 end-page: 274 ident: bib2 article-title: Carcinoma of the oesophagus publication-title: J R Coll Surg Edin contributor: fullname: McKeown – volume: 24 start-page: 253 year: 1979 ident: 10.1016/S0936-6555(05)81056-8_bib2 article-title: Carcinoma of the oesophagus publication-title: J R Coll Surg Edin contributor: fullname: McKeown – volume: 17 start-page: 242 year: 1966 ident: 10.1016/S0936-6555(05)81056-8_bib3 article-title: The radiotherapy of carcinoma of the oesophagus and post-cricoid region in South East Scotland publication-title: Clin Radiol doi: 10.1016/S0009-9260(66)80030-2 contributor: fullname: Pearson – volume: ii start-page: 981 year: 1985 ident: 10.1016/S0936-6555(05)81056-8_bib5 article-title: Intracavitary irradiation in palliation of carcinoma of oesophagus and cardia publication-title: Lancet doi: 10.1016/S0140-6736(85)90527-6 contributor: fullname: Rowland – volume: 9 start-page: 13 year: 1987 ident: 10.1016/S0936-6555(05)81056-8_bib7 article-title: Radiotherapy of esophageal carcinoma. Role of high-dose-rate intracavitary irradiation publication-title: Radiother Oncol doi: 10.1016/S0167-8140(87)80214-1 contributor: fullname: Hishikawa – volume: 159 start-page: 549 year: 1986 ident: 10.1016/S0936-6555(05)81056-8_bib11 article-title: Esophageal fistula associated with intracavitary irradiation for esophageal carcinoma publication-title: Radiology doi: 10.1148/radiology.159.2.3961189 contributor: fullname: Hishikawa – volume: 159 start-page: 715 year: 1986 ident: 10.1016/S0936-6555(05)81056-8_bib9 article-title: Esophageal stricture following high-dose-rate intracavitary irradiation for esophageal cancer publication-title: Radiology doi: 10.1148/radiology.159.3.3704151 contributor: fullname: Hishikawa – volume: 72 start-page: 32 year: 1990 ident: 10.1016/S0936-6555(05)81056-8_bib8 article-title: 101 oesophageal cancers: a surgeon uses radiotherapy publication-title: Ann R Coll Surg Engl contributor: fullname: Earlam – volume: 67 start-page: 457 year: 1980 ident: 10.1016/S0936-6555(05)81056-8_bib1 article-title: Oesophageal squamous cell carcinoma: II. A critical review of radiotherapy publication-title: Br J Surgery doi: 10.1002/bjs.1800670702 contributor: fullname: Earlam – volume: 17 start-page: 937 year: 1989 ident: 10.1016/S0936-6555(05)81056-8_bib6 article-title: Impact of new radiotherapy modalities on surgical management of cancer of the oesophagus and cardia publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(89)90139-9 contributor: fullname: Flores – volume: 35 start-page: 294 year: 1990 ident: 10.1016/S0936-6555(05)81056-8_bib12 article-title: Endoscopic Nd-YAG laser therapy as palliative treatment for esophageal and cardial cancer publication-title: Dig Dis Sci doi: 10.1007/BF01537405 contributor: fullname: Naveau – start-page: 621 year: 1985 ident: 10.1016/S0936-6555(05)81056-8_bib4 article-title: Cancer of the esophagus contributor: fullname: Rosenberg – volume: 2 start-page: 439 year: 1989 ident: 10.1016/S0936-6555(05)81056-8_bib13 article-title: Brachytherapy of carcinoma of the oesophagus in China contributor: fullname: Yin – volume: 2 start-page: 305 year: 1978 ident: 10.1016/S0936-6555(05)81056-8_bib10 article-title: Trauma to the oesophagus publication-title: Gastrointest Radiol doi: 10.1007/BF02256513 contributor: fullname: Love |
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| Snippet | Seventy patients (40 males, 30 female; age 36–87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre,... Seventy patients (40 males, 30 female; age 36-87 years, median 72 years) who were unsuitable for surgery were referred to the Regional Radiotherapy Centre,... |
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| SubjectTerms | Adenocarcinoma - radiotherapy Adult Aged Aged, 80 and over Brachytherapy - adverse effects Carcinoma, Squamous Cell - radiotherapy Deglutition Disorders - etiology Esophageal Neoplasms - complications Esophageal Neoplasms - mortality Esophageal Neoplasms - radiotherapy External radiotherapy Female Humans Intracavitary radiotherapy Male Methods Middle Aged Oesophageal carcinoma Palliative Care Radiotherapy Dosage Survival Rate |
| Title | Combined external beam and intracavitary radiotherapy in oesophageal carcinoma |
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