Toxicological studies with a hydrocarbon solvent, SBP 62/82
Acute and subacute toxicity studies of the hydrocarbon solvent, SBP 62/82, have been carried out in rats and dogs. The acute oral LD 50 in rats exceeded 20 ml/kg. No adverse effects attributable to the solvent were noted after thrice-weekly oral doses of 1 or 5 ml/kg of SBP to rats for 13 wk; once-w...
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Published in | Food and cosmetics toxicology Vol. 5; no. 1; pp. 19 - 22 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier B.V
1967
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Subjects | |
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Abstract | Acute and subacute toxicity studies of the hydrocarbon solvent, SBP 62/82, have been carried out in rats and dogs. The acute oral LD
50 in rats exceeded 20 ml/kg. No adverse effects attributable to the solvent were noted after thrice-weekly oral doses of 1 or 5 ml/kg of SBP to rats for 13 wk; once-weekly oral doses of 0.5 or 2.5 ml/kg of a 20% emulsion of SBP to rats for 26 wk; or daily graded oral doses of 0–0.5 ml/kg of SBP to dogs for 24 wk.
On a fait des études sur la toxicité aiguë et subaiguë du solvant d'hydrocarbure SBP 62/82 sur des rats et des chiens. La DL
50 orale aiguë chez les rats a dépassé 20 ml/kg. On n'a constaté aucun effet nocif attribuable au solvant, après l'administration par voie orale de trois doses par semaine de 1 ou 5 ml/kg de SBP à des rats pendant 13 semaines, après l'administration orale d'une dose par semaine de 0,5 ou 2,5 ml/kg d'une émulsion de 20% de SBP à des rats pendant 26 semaines, ou après l'administration orale quotidienne progressivement augmentée de 0 à 0,5 ml/kg de SBP à des chiens pendant 24 semaines.
Akute und subakute Toxizitätsuntersuchungen mit dem Kohlenwasserstoff-Lösungsmittel SBP 62/82 wurden an Ratten und Hunden durchgeführt. Die akute orale LD
50 für Ratten überschritt 20 ml/kg. Keine dem Lösungsmittel zuzuschreibende nachteilige Wirkungen wurden nach 13 Wochen an Ratten verfütterten dreimal wöchentlichen Dosen von 1 oder 5 ml/kg SBP, nach 26 Wochen an Ratten verfütterten einmal wöchentlichen Dosen von 0,5 oder 2,5 ml/kg einer 20%igen Emulsion von SBP oder nach 24 Wochen an Hunde verfütterten täglichen abgestuften Dosen von 0 zu 0,5 ml/kg SBP beobachtet. |
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AbstractList | Acute and subacute toxicity studies of the hydrocarbon solvent, SBP 62/82, have been carried out in rats and dogs. The acute oral LD
50 in rats exceeded 20 ml/kg. No adverse effects attributable to the solvent were noted after thrice-weekly oral doses of 1 or 5 ml/kg of SBP to rats for 13 wk; once-weekly oral doses of 0.5 or 2.5 ml/kg of a 20% emulsion of SBP to rats for 26 wk; or daily graded oral doses of 0–0.5 ml/kg of SBP to dogs for 24 wk.
On a fait des études sur la toxicité aiguë et subaiguë du solvant d'hydrocarbure SBP 62/82 sur des rats et des chiens. La DL
50 orale aiguë chez les rats a dépassé 20 ml/kg. On n'a constaté aucun effet nocif attribuable au solvant, après l'administration par voie orale de trois doses par semaine de 1 ou 5 ml/kg de SBP à des rats pendant 13 semaines, après l'administration orale d'une dose par semaine de 0,5 ou 2,5 ml/kg d'une émulsion de 20% de SBP à des rats pendant 26 semaines, ou après l'administration orale quotidienne progressivement augmentée de 0 à 0,5 ml/kg de SBP à des chiens pendant 24 semaines.
Akute und subakute Toxizitätsuntersuchungen mit dem Kohlenwasserstoff-Lösungsmittel SBP 62/82 wurden an Ratten und Hunden durchgeführt. Die akute orale LD
50 für Ratten überschritt 20 ml/kg. Keine dem Lösungsmittel zuzuschreibende nachteilige Wirkungen wurden nach 13 Wochen an Ratten verfütterten dreimal wöchentlichen Dosen von 1 oder 5 ml/kg SBP, nach 26 Wochen an Ratten verfütterten einmal wöchentlichen Dosen von 0,5 oder 2,5 ml/kg einer 20%igen Emulsion von SBP oder nach 24 Wochen an Hunde verfütterten täglichen abgestuften Dosen von 0 zu 0,5 ml/kg SBP beobachtet. |
Author | Walker, A.I.T. Stevenson, D.E. |
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Cites_doi | 10.1021/ja01571a093 |
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Copyright | 1967 Pergamon Press Limited |
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References | Cornelius, Kaneko (bib1) 1963 Pritchard, Rehfeld, Sautter (bib8) 1952; 121 Fincher (bib2) 1958 McKinney, Weakley, Eldridge, Campbell, Cowan, Picken, Biester (bib5) 1957; 79 Poppleton (bib7) 1965; 2 Nelson, Ege, Ross, Woodman, Silverman (bib6) 1943; 25 Holm, Eveleth, Dinusson (bib4) 1953; 122 Fühner (bib3) 1921; 155 Pritchard (10.1016/S0015-6264(67)82881-5_bib8) 1952; 121 Cornelius (10.1016/S0015-6264(67)82881-5_bib1) 1963 Fincher (10.1016/S0015-6264(67)82881-5_bib2) 1958 Holm (10.1016/S0015-6264(67)82881-5_bib4) 1953; 122 McKinney (10.1016/S0015-6264(67)82881-5_bib5) 1957; 79 Fühner (10.1016/S0015-6264(67)82881-5_bib3) 1921; 155 Poppleton (10.1016/S0015-6264(67)82881-5_bib7) 1965; 2 Nelson (10.1016/S0015-6264(67)82881-5_bib6) 1943; 25 |
References_xml | – volume: 121 start-page: 1 year: 1952 ident: bib8 article-title: Aplastic anemia of cattle associated with ingestion of trichloroethylene extracted soybean meal publication-title: J. Am. vet. Med. Ass. contributor: fullname: Sautter – volume: 122 start-page: 380 year: 1953 ident: bib4 article-title: Trichloroethylene soybean meal poisoning in sheep publication-title: J. Am. vet. med. Ass. contributor: fullname: Dinusson – volume: 79 start-page: 3932 year: 1957 ident: bib5 article-title: S-(dichlorovinyl)- publication-title: J. Am. chem. Soc. contributor: fullname: Biester – start-page: 225 year: 1963 ident: bib1 publication-title: Clinical Biochemistry of Domestic Animals contributor: fullname: Kaneko – volume: 25 start-page: 282 year: 1943 ident: bib6 article-title: Sensory response to certain industrial vapours publication-title: J. ind. Hyg. Toxicol. contributor: fullname: Silverman – volume: 2 start-page: 2 year: 1965 ident: bib7 article-title: Oral dosing of the dog—capsule injection publication-title: Bull. Anim. Tech. Ass. contributor: fullname: Poppleton – start-page: 67 year: 1958 ident: bib2 article-title: Processing of oil seeds in Processed Plant Protein Foodstuffs contributor: fullname: Fincher – volume: 155 start-page: 235 year: 1921 ident: bib3 article-title: Die Nakotische Wirkung des Benzins und seiner Bestandteile publication-title: Biochem. Z. contributor: fullname: Fühner – start-page: 225 year: 1963 ident: 10.1016/S0015-6264(67)82881-5_bib1 contributor: fullname: Cornelius – start-page: 67 year: 1958 ident: 10.1016/S0015-6264(67)82881-5_bib2 article-title: Processing of oil seeds in Processed Plant Protein Foodstuffs contributor: fullname: Fincher – volume: 122 start-page: 380 year: 1953 ident: 10.1016/S0015-6264(67)82881-5_bib4 article-title: Trichloroethylene soybean meal poisoning in sheep publication-title: J. Am. vet. med. Ass. contributor: fullname: Holm – volume: 121 start-page: 1 year: 1952 ident: 10.1016/S0015-6264(67)82881-5_bib8 article-title: Aplastic anemia of cattle associated with ingestion of trichloroethylene extracted soybean meal publication-title: J. Am. vet. Med. Ass. contributor: fullname: Pritchard – volume: 155 start-page: 235 year: 1921 ident: 10.1016/S0015-6264(67)82881-5_bib3 article-title: Die Nakotische Wirkung des Benzins und seiner Bestandteile publication-title: Biochem. Z. contributor: fullname: Fühner – volume: 79 start-page: 3932 year: 1957 ident: 10.1016/S0015-6264(67)82881-5_bib5 article-title: S-(dichlorovinyl)-l-cysteine: an agent causing fatal aplastic anemia in calves publication-title: J. Am. chem. Soc. doi: 10.1021/ja01571a093 contributor: fullname: McKinney – volume: 25 start-page: 282 year: 1943 ident: 10.1016/S0015-6264(67)82881-5_bib6 article-title: Sensory response to certain industrial vapours publication-title: J. ind. Hyg. Toxicol. contributor: fullname: Nelson – volume: 2 start-page: 2 year: 1965 ident: 10.1016/S0015-6264(67)82881-5_bib7 article-title: Oral dosing of the dog—capsule injection publication-title: Bull. Anim. Tech. Ass. contributor: fullname: Poppleton |
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Snippet | Acute and subacute toxicity studies of the hydrocarbon solvent, SBP 62/82, have been carried out in rats and dogs. The acute oral LD
50 in rats exceeded 20... |
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SubjectTerms | Animals Dogs Emulsions Hydrocarbons - administration & dosage Hydrocarbons - toxicity Rats Solvents - toxicity |
Title | Toxicological studies with a hydrocarbon solvent, SBP 62/82 |
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