Enhanced B7-2 Gene Expression by Interferon-γ in Human Monocytic Cells Is Controlled Through Transcriptional and Posttranscriptional Mechanisms

• Published in: Blood Vol. 94; no. 5; pp. 1782 - 1789
• Main Authors: Curiel, R.E., Garcia, C.S., Rottschafer, S., Bosco, M.C., Espinoza-Delgado, I.
• Format: Journal Article
• Language: English
• Published: 01.09.1999

B7-2 is a costimulatory molecule expressed on professional antigen-presenting cells that provides T cells with a critical signal resulting in T-cell activation. Interferon-γ (IFN-γ) enhances B7-2 protein expression in monocytic cells. However, the molecular mechanisms controlling the enhanced expres...